Transcription coordinates histone amounts and genome content

Transcription coordinates histone amounts and genome content

Accurate regulation of protein concentrations according to changes in cell volume that accompany growth and changes in biosynthetic capacity is an important component of cellular homeostasis. Here, using the model organism S. cerevisiae, the authors show how histone production is quantitatively coup...

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Main Authors: Kora-Lee Claude, Daniela Bureik, Dimitra Chatzitheodoridou, Petia Adarska, Abhyudai Singh, Kurt M. Schmoller
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24451-8
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spelling doaj-5b228a49de404295a27fdb7a29d0d3e82021-07-11T11:42:21ZengNature Publishing GroupNature Communications2041-17232021-07-0112111710.1038/s41467-021-24451-8Transcription coordinates histone amounts and genome contentKora-Lee Claude0Daniela Bureik1Dimitra Chatzitheodoridou2Petia Adarska3Abhyudai Singh4Kurt M. Schmoller5Institute of Functional Epigenetics, Helmholtz Zentrum MünchenInstitute of Functional Epigenetics, Helmholtz Zentrum MünchenInstitute of Functional Epigenetics, Helmholtz Zentrum MünchenInstitute of Functional Epigenetics, Helmholtz Zentrum MünchenDepartment of Electrical & Computer Engineering, University of DelawareInstitute of Functional Epigenetics, Helmholtz Zentrum MünchenAccurate regulation of protein concentrations according to changes in cell volume that accompany growth and changes in biosynthetic capacity is an important component of cellular homeostasis. Here, using the model organism S. cerevisiae, the authors show how histone production is quantitatively coupled to genome content through the intrinsic properties of histone promoters.https://doi.org/10.1038/s41467-021-24451-8
collection DOAJ
language English
format Article
sources DOAJ
author Kora-Lee Claude
Daniela Bureik
Dimitra Chatzitheodoridou
Petia Adarska
Abhyudai Singh
Kurt M. Schmoller
spellingShingle Kora-Lee Claude
Daniela Bureik
Dimitra Chatzitheodoridou
Petia Adarska
Abhyudai Singh
Kurt M. Schmoller
Transcription coordinates histone amounts and genome content
Nature Communications
author_facet Kora-Lee Claude
Daniela Bureik
Dimitra Chatzitheodoridou
Petia Adarska
Abhyudai Singh
Kurt M. Schmoller
author_sort Kora-Lee Claude
title Transcription coordinates histone amounts and genome content
title_short Transcription coordinates histone amounts and genome content
title_full Transcription coordinates histone amounts and genome content
title_fullStr Transcription coordinates histone amounts and genome content
title_full_unstemmed Transcription coordinates histone amounts and genome content
title_sort transcription coordinates histone amounts and genome content
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-07-01
description Accurate regulation of protein concentrations according to changes in cell volume that accompany growth and changes in biosynthetic capacity is an important component of cellular homeostasis. Here, using the model organism S. cerevisiae, the authors show how histone production is quantitatively coupled to genome content through the intrinsic properties of histone promoters.
url https://doi.org/10.1038/s41467-021-24451-8
work_keys_str_mv AT koraleeclaude transcriptioncoordinateshistoneamountsandgenomecontent
AT danielabureik transcriptioncoordinateshistoneamountsandgenomecontent
AT dimitrachatzitheodoridou transcriptioncoordinateshistoneamountsandgenomecontent
AT petiaadarska transcriptioncoordinateshistoneamountsandgenomecontent
AT abhyudaisingh transcriptioncoordinateshistoneamountsandgenomecontent
AT kurtmschmoller transcriptioncoordinateshistoneamountsandgenomecontent
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