Therapeutic Potential of Volatile Terpenes and Terpenoids from Forests for Inflammatory Diseases
Forest trees are a major source of biogenic volatile organic compounds (BVOCs). Terpenes and terpenoids are known as the main BVOCs of forest aerosols. These compounds have been shown to display a broad range of biological activities in various human disease models, thus implying that forest aerosol...
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doaj-5b287aa1135145ef8a6c578444dd53d72020-11-25T03:50:59ZengMDPI AGInternational Journal of Molecular Sciences1422-00672020-03-01216218710.3390/ijms21062187ijms21062187Therapeutic Potential of Volatile Terpenes and Terpenoids from Forests for Inflammatory DiseasesTaejoon Kim0Bokyeong Song1Kyoung Sang Cho2Im-Soon Lee3Department of Biological Sciences, Research Center for Coupled Human and Natural Systems for Ecowelfare, Konkuk University, Seoul 05029, KoreaDepartment of Biological Sciences, Research Center for Coupled Human and Natural Systems for Ecowelfare, Konkuk University, Seoul 05029, KoreaDepartment of Biological Sciences, Research Center for Coupled Human and Natural Systems for Ecowelfare, Konkuk University, Seoul 05029, KoreaDepartment of Biological Sciences, Research Center for Coupled Human and Natural Systems for Ecowelfare, Konkuk University, Seoul 05029, KoreaForest trees are a major source of biogenic volatile organic compounds (BVOCs). Terpenes and terpenoids are known as the main BVOCs of forest aerosols. These compounds have been shown to display a broad range of biological activities in various human disease models, thus implying that forest aerosols containing these compounds may be related to beneficial effects of forest bathing. In this review, we surveyed studies analyzing BVOCs and selected the most abundant 23 terpenes and terpenoids emitted in forested areas of the Northern Hemisphere, which were reported to display anti-inflammatory activities. We categorized anti-inflammatory processes related to the functions of these compounds into six groups and summarized their molecular mechanisms of action. Finally, among the major 23 compounds, we examined the therapeutic potentials of 12 compounds known to be effective against respiratory inflammation, atopic dermatitis, arthritis, and neuroinflammation among various inflammatory diseases. In conclusion, the updated studies support the beneficial effects of forest aerosols and propose their potential use as chemopreventive and therapeutic agents for treating various inflammatory diseases.https://www.mdpi.com/1422-0067/21/6/2187bvocterpeneterpenoidforest aerosolanti-inflammation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Taejoon Kim Bokyeong Song Kyoung Sang Cho Im-Soon Lee |
spellingShingle |
Taejoon Kim Bokyeong Song Kyoung Sang Cho Im-Soon Lee Therapeutic Potential of Volatile Terpenes and Terpenoids from Forests for Inflammatory Diseases International Journal of Molecular Sciences bvoc terpene terpenoid forest aerosol anti-inflammation |
author_facet |
Taejoon Kim Bokyeong Song Kyoung Sang Cho Im-Soon Lee |
author_sort |
Taejoon Kim |
title |
Therapeutic Potential of Volatile Terpenes and Terpenoids from Forests for Inflammatory Diseases |
title_short |
Therapeutic Potential of Volatile Terpenes and Terpenoids from Forests for Inflammatory Diseases |
title_full |
Therapeutic Potential of Volatile Terpenes and Terpenoids from Forests for Inflammatory Diseases |
title_fullStr |
Therapeutic Potential of Volatile Terpenes and Terpenoids from Forests for Inflammatory Diseases |
title_full_unstemmed |
Therapeutic Potential of Volatile Terpenes and Terpenoids from Forests for Inflammatory Diseases |
title_sort |
therapeutic potential of volatile terpenes and terpenoids from forests for inflammatory diseases |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2020-03-01 |
description |
Forest trees are a major source of biogenic volatile organic compounds (BVOCs). Terpenes and terpenoids are known as the main BVOCs of forest aerosols. These compounds have been shown to display a broad range of biological activities in various human disease models, thus implying that forest aerosols containing these compounds may be related to beneficial effects of forest bathing. In this review, we surveyed studies analyzing BVOCs and selected the most abundant 23 terpenes and terpenoids emitted in forested areas of the Northern Hemisphere, which were reported to display anti-inflammatory activities. We categorized anti-inflammatory processes related to the functions of these compounds into six groups and summarized their molecular mechanisms of action. Finally, among the major 23 compounds, we examined the therapeutic potentials of 12 compounds known to be effective against respiratory inflammation, atopic dermatitis, arthritis, and neuroinflammation among various inflammatory diseases. In conclusion, the updated studies support the beneficial effects of forest aerosols and propose their potential use as chemopreventive and therapeutic agents for treating various inflammatory diseases. |
topic |
bvoc terpene terpenoid forest aerosol anti-inflammation |
url |
https://www.mdpi.com/1422-0067/21/6/2187 |
work_keys_str_mv |
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