Distinct Roles for Two Chromosome 1 Loci in Ethanol Withdrawal, Consumption, and Conditioned Place Preference

Distinct Roles for Two Chromosome 1 Loci in Ethanol Withdrawal, Consumption, and Conditioned Place Preference

We previously identified a region on chromosome 1 that harbor quantitative trait loci (QTLs) with large effects on alcohol withdrawal risk using both chronic and acute models in mice. Here, using newly created and existing QTL interval-specific congenic (ISC) models, we report the first evidence tha...

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Bibliographic Details
Main Authors: Laura B. Kozell, Deaunne L. Denmark, Nicole A. R. Walter, Kari J. Buck
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Genetics
Subjects:
quantitative trait locus (QTL)
anxiety
convulsions
consumption
GIRK
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00323/full

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