Bioengineered microfluidic blood-brain barrier models in oncology research
Metastasis is the major reason for most brain tumors with up to a 50% chance of occurrence in patients with other types of malignancies. Brain metastasis occurs if cancer cells succeed to cross the ‘blood-brain barrier’ (BBB). Moreover, changes in the structure and function of BBB can lead to the on...
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doaj-5b4599b77d8b4c218f5d2cbb90e39c8d2021-05-24T04:29:56ZengElsevierTranslational Oncology1936-52332021-07-01147101087Bioengineered microfluidic blood-brain barrier models in oncology researchRobin Augustine0Ahmad H. Aqel1Sumama Nuthana Kalva2K.S. Joshy3Ajisha Nayeem4Anwarul Hasan5Department of Mechanical and Industrial Engineering, College of Engineering, Qatar University, 2713 Doha, Qatar; Biomedical Research Center (BRC), Qatar University, PO Box 2713 Doha, Qatar; Corresponding authors.Department of Mechanical and Industrial Engineering, College of Engineering, Qatar University, 2713 Doha, Qatar; Biomedical Research Center (BRC), Qatar University, PO Box 2713 Doha, QatarDepartment of Mechanical and Industrial Engineering, College of Engineering, Qatar University, 2713 Doha, Qatar; Biomedical Research Center (BRC), Qatar University, PO Box 2713 Doha, QatarDepartment of Mechanical and Industrial Engineering, College of Engineering, Qatar University, 2713 Doha, Qatar; Biomedical Research Center (BRC), Qatar University, PO Box 2713 Doha, QatarDepartment of Biotechnology, St. Mary's College, Thrissur 680020, Kerala, IndiaDepartment of Mechanical and Industrial Engineering, College of Engineering, Qatar University, 2713 Doha, Qatar; Biomedical Research Center (BRC), Qatar University, PO Box 2713 Doha, Qatar; Corresponding authors.Metastasis is the major reason for most brain tumors with up to a 50% chance of occurrence in patients with other types of malignancies. Brain metastasis occurs if cancer cells succeed to cross the ‘blood-brain barrier’ (BBB). Moreover, changes in the structure and function of BBB can lead to the onset and progression of diseases including neurological disorders and brain-metastases. Generating BBB models with structural and functional features of intact BBB is highly important to better understand the molecular mechanism of such ailments and finding novel therapeutic agents targeting them. Hence, researchers are developing novel in vitro BBB platforms that can recapitulate the structural and functional characteristics of BBB. Brain endothelial cells-based in vitro BBB models have thus been developed to investigate the mechanism of brain metastasis through BBB and facilitate the testing of brain targeted anticancer drugs. Bioengineered constructs integrated with microfluidic platforms are vital tools for recapitulating the features of BBB in vitro closely as possible. In this review, we outline the fundamentals of BBB biology, recent developments in the microfluidic BBB platforms, and provide a concise discussion of diverse types of bioengineered BBB models with an emphasis on the application of them in brain metastasis and cancer research in general. We also provide insights into the challenges and prospects of the current bioengineered microfluidic platforms in cancer research.http://www.sciencedirect.com/science/article/pii/S1936523321000796Blood-brain barrierBBB modelsMicrofluidicsMicroenvironmentCancerMetastasis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Robin Augustine Ahmad H. Aqel Sumama Nuthana Kalva K.S. Joshy Ajisha Nayeem Anwarul Hasan |
spellingShingle |
Robin Augustine Ahmad H. Aqel Sumama Nuthana Kalva K.S. Joshy Ajisha Nayeem Anwarul Hasan Bioengineered microfluidic blood-brain barrier models in oncology research Translational Oncology Blood-brain barrier BBB models Microfluidics Microenvironment Cancer Metastasis |
author_facet |
Robin Augustine Ahmad H. Aqel Sumama Nuthana Kalva K.S. Joshy Ajisha Nayeem Anwarul Hasan |
author_sort |
Robin Augustine |
title |
Bioengineered microfluidic blood-brain barrier models in oncology research |
title_short |
Bioengineered microfluidic blood-brain barrier models in oncology research |
title_full |
Bioengineered microfluidic blood-brain barrier models in oncology research |
title_fullStr |
Bioengineered microfluidic blood-brain barrier models in oncology research |
title_full_unstemmed |
Bioengineered microfluidic blood-brain barrier models in oncology research |
title_sort |
bioengineered microfluidic blood-brain barrier models in oncology research |
publisher |
Elsevier |
series |
Translational Oncology |
issn |
1936-5233 |
publishDate |
2021-07-01 |
description |
Metastasis is the major reason for most brain tumors with up to a 50% chance of occurrence in patients with other types of malignancies. Brain metastasis occurs if cancer cells succeed to cross the ‘blood-brain barrier’ (BBB). Moreover, changes in the structure and function of BBB can lead to the onset and progression of diseases including neurological disorders and brain-metastases. Generating BBB models with structural and functional features of intact BBB is highly important to better understand the molecular mechanism of such ailments and finding novel therapeutic agents targeting them. Hence, researchers are developing novel in vitro BBB platforms that can recapitulate the structural and functional characteristics of BBB. Brain endothelial cells-based in vitro BBB models have thus been developed to investigate the mechanism of brain metastasis through BBB and facilitate the testing of brain targeted anticancer drugs. Bioengineered constructs integrated with microfluidic platforms are vital tools for recapitulating the features of BBB in vitro closely as possible. In this review, we outline the fundamentals of BBB biology, recent developments in the microfluidic BBB platforms, and provide a concise discussion of diverse types of bioengineered BBB models with an emphasis on the application of them in brain metastasis and cancer research in general. We also provide insights into the challenges and prospects of the current bioengineered microfluidic platforms in cancer research. |
topic |
Blood-brain barrier BBB models Microfluidics Microenvironment Cancer Metastasis |
url |
http://www.sciencedirect.com/science/article/pii/S1936523321000796 |
work_keys_str_mv |
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