The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer
<p>Abstract</p> <p>The role of vitamin D (VitD) in calcium and bone homeostasis is well described. In the last years, it has been recognized that in addition to this classical function, VitD modulates a variety of processes and regulatory systems including host defense, inflammatio...
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doaj-5b4aa337b067422e8eb8dbd1bd6aee612020-11-24T21:20:19ZengBMCRespiratory Research1465-99212011-03-011213110.1186/1465-9921-12-31The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancerZakharkina TetyanaMeyer SilkeKoczulla Rembert AGreulich TimmHerr ChristianBranscheidt MeretEschmann RebeccaBals Robert<p>Abstract</p> <p>The role of vitamin D (VitD) in calcium and bone homeostasis is well described. In the last years, it has been recognized that in addition to this classical function, VitD modulates a variety of processes and regulatory systems including host defense, inflammation, immunity, and repair. VitD deficiency appears to be frequent in industrialized countries. Especially patients with lung diseases have often low VitD serum levels. Epidemiological data indicate that low levels of serum VitD is associated with impaired pulmonary function, increased incidence of inflammatory, infectious or neoplastic diseases. Several lung diseases, all inflammatory in nature, may be related to activities of VitD including asthma, COPD and cancer. The exact mechanisms underlying these data are unknown, however, VitD appears to impact on the function of inflammatory and structural cells, including dendritic cells, lymphocytes, monocytes, and epithelial cells. This review summarizes the knowledge on the classical and newly discovered functions of VitD, the molecular and cellular mechanism of action and the available data on the relationship between lung disease and VitD status.</p> http://respiratory-research.com/content/12/1/31Vitamin DmortalityasthmaCOPDrespiratory tract infectionimmunity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zakharkina Tetyana Meyer Silke Koczulla Rembert A Greulich Timm Herr Christian Branscheidt Meret Eschmann Rebecca Bals Robert |
spellingShingle |
Zakharkina Tetyana Meyer Silke Koczulla Rembert A Greulich Timm Herr Christian Branscheidt Meret Eschmann Rebecca Bals Robert The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer Respiratory Research Vitamin D mortality asthma COPD respiratory tract infection immunity |
author_facet |
Zakharkina Tetyana Meyer Silke Koczulla Rembert A Greulich Timm Herr Christian Branscheidt Meret Eschmann Rebecca Bals Robert |
author_sort |
Zakharkina Tetyana |
title |
The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer |
title_short |
The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer |
title_full |
The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer |
title_fullStr |
The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer |
title_full_unstemmed |
The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer |
title_sort |
role of vitamin d in pulmonary disease: copd, asthma, infection, and cancer |
publisher |
BMC |
series |
Respiratory Research |
issn |
1465-9921 |
publishDate |
2011-03-01 |
description |
<p>Abstract</p> <p>The role of vitamin D (VitD) in calcium and bone homeostasis is well described. In the last years, it has been recognized that in addition to this classical function, VitD modulates a variety of processes and regulatory systems including host defense, inflammation, immunity, and repair. VitD deficiency appears to be frequent in industrialized countries. Especially patients with lung diseases have often low VitD serum levels. Epidemiological data indicate that low levels of serum VitD is associated with impaired pulmonary function, increased incidence of inflammatory, infectious or neoplastic diseases. Several lung diseases, all inflammatory in nature, may be related to activities of VitD including asthma, COPD and cancer. The exact mechanisms underlying these data are unknown, however, VitD appears to impact on the function of inflammatory and structural cells, including dendritic cells, lymphocytes, monocytes, and epithelial cells. This review summarizes the knowledge on the classical and newly discovered functions of VitD, the molecular and cellular mechanism of action and the available data on the relationship between lung disease and VitD status.</p> |
topic |
Vitamin D mortality asthma COPD respiratory tract infection immunity |
url |
http://respiratory-research.com/content/12/1/31 |
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