Systemic Arthritis in Children: A Review of Clinical Presentation and Treatment

Systemic Arthritis in Children: A Review of Clinical Presentation and Treatment

Systemic juvenile idiopathic arthritis (sJIA) constitutes a small part of juvenile idiopathic arthritis (JIA), yet has a disproportionally higher rate of mortality. Despite being grouped under JIA, it is considered to be a multifactorial autoinflammatory disease. The objective of this paper is to re...

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Main Authors: R. Gurion, T. J. A. Lehman, L. N. Moorthy
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:International Journal of Inflammation
Online Access:http://dx.doi.org/10.1155/2012/271569
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spelling doaj-5b57e77c34464fa085fed3bdc8f029292020-11-24T21:02:54ZengHindawi LimitedInternational Journal of Inflammation2090-80402042-00992012-01-01201210.1155/2012/271569271569Systemic Arthritis in Children: A Review of Clinical Presentation and TreatmentR. Gurion0T. J. A. Lehman1L. N. Moorthy2Division of Pediatric Rheumatology, Rainbow Babies & Children's Hospital, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106, USADivision of Pediatric Rheumatology, Hospital for Special Surgery and Clinical Pediatrics Weill Medical Center, Cornell University, 535 E 70 St, New York, NY 10021, USADivision of Pediatric Rheumatology, Department of Pediatrics, University of Medicine and Dentistry of NJ-Robert Wood Johnson Medical School, 89 French Street, New Brunswick, NJ 08901, USASystemic juvenile idiopathic arthritis (sJIA) constitutes a small part of juvenile idiopathic arthritis (JIA), yet has a disproportionally higher rate of mortality. Despite being grouped under JIA, it is considered to be a multifactorial autoinflammatory disease. The objective of this paper is to review the epidemiology, pathogenesis, genetics, clinical manifestations, complications, therapy, prognosis, and outcome of sJIA. The presentation and clinical manifestations of sJIA have not changed much in the past several decades, but the collective understanding of the pathogenesis and the development of new targeted therapies (particularly the biologic agents) have transformed and improved the disease outcome for children with sJIA.http://dx.doi.org/10.1155/2012/271569
collection DOAJ
language English
format Article
sources DOAJ
author R. Gurion
T. J. A. Lehman
L. N. Moorthy
spellingShingle R. Gurion
T. J. A. Lehman
L. N. Moorthy
Systemic Arthritis in Children: A Review of Clinical Presentation and Treatment
International Journal of Inflammation
author_facet R. Gurion
T. J. A. Lehman
L. N. Moorthy
author_sort R. Gurion
title Systemic Arthritis in Children: A Review of Clinical Presentation and Treatment
title_short Systemic Arthritis in Children: A Review of Clinical Presentation and Treatment
title_full Systemic Arthritis in Children: A Review of Clinical Presentation and Treatment
title_fullStr Systemic Arthritis in Children: A Review of Clinical Presentation and Treatment
title_full_unstemmed Systemic Arthritis in Children: A Review of Clinical Presentation and Treatment
title_sort systemic arthritis in children: a review of clinical presentation and treatment
publisher Hindawi Limited
series International Journal of Inflammation
issn 2090-8040
2042-0099
publishDate 2012-01-01
description Systemic juvenile idiopathic arthritis (sJIA) constitutes a small part of juvenile idiopathic arthritis (JIA), yet has a disproportionally higher rate of mortality. Despite being grouped under JIA, it is considered to be a multifactorial autoinflammatory disease. The objective of this paper is to review the epidemiology, pathogenesis, genetics, clinical manifestations, complications, therapy, prognosis, and outcome of sJIA. The presentation and clinical manifestations of sJIA have not changed much in the past several decades, but the collective understanding of the pathogenesis and the development of new targeted therapies (particularly the biologic agents) have transformed and improved the disease outcome for children with sJIA.
url http://dx.doi.org/10.1155/2012/271569
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AT tjalehman systemicarthritisinchildrenareviewofclinicalpresentationandtreatment
AT lnmoorthy systemicarthritisinchildrenareviewofclinicalpresentationandtreatment
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