Tenectin recruits integrin to stabilize bouton architecture and regulate vesicle release at the Drosophila neuromuscular junction

Tenectin recruits integrin to stabilize bouton architecture and regulate vesicle release at the Drosophila neuromuscular junction

Assembly, maintenance and function of synaptic junctions depend on extracellular matrix (ECM) proteins and their receptors. Here we report that Tenectin (Tnc), a Mucin-type protein with RGD motifs, is an ECM component required for the structural and functional integrity of synaptic specializations a...

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Bibliographic Details
Main Authors: Qi Wang, Tae Hee Han, Peter Nguyen, Michal Jarnik, Mihaela Serpe
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-06-01
Series:eLife
Subjects:
extracellular matrix
integrin
synaptic terminals
neuromuscular junction
Online Access:https://elifesciences.org/articles/35518

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