Relationship between disease severity and D-dimer levels measured with two different methods in pulmonary embolism patients
<p>Abstract</p> <p>Pulmonary embolism (PE) is diagnosed with increasing frequency nowadays due to advances in the diagnostic methods and the increased awareness of the disease. There is a tendency to use non invasive diagnostic methods for all diseases. D-dimer is a fibrin degradat...
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doaj-5b5e1bb357614cb688df6171741e91092020-11-25T03:31:48ZengPAGEPress PublicationsMultidisciplinary Respiratory Medicine2049-69582010-06-015316817210.1186/2049-6958-5-3-168Relationship between disease severity and D-dimer levels measured with two different methods in pulmonary embolism patientsCoskun FundaYilmaz DilberUrsavas AhmetUzaslan EsraEge Ercument<p>Abstract</p> <p>Pulmonary embolism (PE) is diagnosed with increasing frequency nowadays due to advances in the diagnostic methods and the increased awareness of the disease. There is a tendency to use non invasive diagnostic methods for all diseases. D-dimer is a fibrin degradation product. We aimed to detect the relationship between disease severity and the D-dimer levels measured with two different methods. We compared D-dimer levels in cases of massive vs. non-massive PE. A total of 89 patients who were diagnosed between 2006 and 2008 were included in the study. Group 1 included patients whose D-dimer levels were measured with the immunoturbidimetric polyclonal antibody method (D-dimerPLUS<sup>®</sup>), while Group 2 patients made use of the immunoturbidimetric monoclonal antibody method (InnovanceD-DIMER<sup>®</sup>). In each group, the D-dimer levels of those with massive and non-massive PE were compared, using the Mann Whitney U test. The mean age of Group 1 (25 F/26 M) was 56.0 ± 17.9 years, and that of Group 2 (22 F/16 M) was 52.9 ± 17.9 years. There was no statistical difference in gender and mean age between the two groups (p > 0.05). In Group 1, the mean D-dimer level of massive cases (n = 7) was 1444.9 ± 657.9 μg/L and that of nonmassive PE (n = 34) was 1304.7 ± 350.5 μg/L (p > 0.05). In Group 2, the mean D-dimer level of massive cases (n = 6) was 9.7 ± 2.2 mg/L and that of non-massive PE (n = 32) was 5.9 ± 1.3 mg/L (p < 0.05). The mean D-dimer levels of massive cases as measured with the immunoturbidimetric monoclonal antibody method were significantly higher. Pulmonary embolism patients whose D-dimer levels are higher (especially higher than 6.6 mg/L) should be considered as possibly having massive embolism. Diagnostic procedures and management can be planned according to this finding.</p> http://www.mrmjournal.com/content/5/3/168D-dimermassive pulmonary embolismpulmonary embolism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Coskun Funda Yilmaz Dilber Ursavas Ahmet Uzaslan Esra Ege Ercument |
spellingShingle |
Coskun Funda Yilmaz Dilber Ursavas Ahmet Uzaslan Esra Ege Ercument Relationship between disease severity and D-dimer levels measured with two different methods in pulmonary embolism patients Multidisciplinary Respiratory Medicine D-dimer massive pulmonary embolism pulmonary embolism |
author_facet |
Coskun Funda Yilmaz Dilber Ursavas Ahmet Uzaslan Esra Ege Ercument |
author_sort |
Coskun Funda |
title |
Relationship between disease severity and D-dimer levels measured with two different methods in pulmonary embolism patients |
title_short |
Relationship between disease severity and D-dimer levels measured with two different methods in pulmonary embolism patients |
title_full |
Relationship between disease severity and D-dimer levels measured with two different methods in pulmonary embolism patients |
title_fullStr |
Relationship between disease severity and D-dimer levels measured with two different methods in pulmonary embolism patients |
title_full_unstemmed |
Relationship between disease severity and D-dimer levels measured with two different methods in pulmonary embolism patients |
title_sort |
relationship between disease severity and d-dimer levels measured with two different methods in pulmonary embolism patients |
publisher |
PAGEPress Publications |
series |
Multidisciplinary Respiratory Medicine |
issn |
2049-6958 |
publishDate |
2010-06-01 |
description |
<p>Abstract</p> <p>Pulmonary embolism (PE) is diagnosed with increasing frequency nowadays due to advances in the diagnostic methods and the increased awareness of the disease. There is a tendency to use non invasive diagnostic methods for all diseases. D-dimer is a fibrin degradation product. We aimed to detect the relationship between disease severity and the D-dimer levels measured with two different methods. We compared D-dimer levels in cases of massive vs. non-massive PE. A total of 89 patients who were diagnosed between 2006 and 2008 were included in the study. Group 1 included patients whose D-dimer levels were measured with the immunoturbidimetric polyclonal antibody method (D-dimerPLUS<sup>®</sup>), while Group 2 patients made use of the immunoturbidimetric monoclonal antibody method (InnovanceD-DIMER<sup>®</sup>). In each group, the D-dimer levels of those with massive and non-massive PE were compared, using the Mann Whitney U test. The mean age of Group 1 (25 F/26 M) was 56.0 ± 17.9 years, and that of Group 2 (22 F/16 M) was 52.9 ± 17.9 years. There was no statistical difference in gender and mean age between the two groups (p > 0.05). In Group 1, the mean D-dimer level of massive cases (n = 7) was 1444.9 ± 657.9 μg/L and that of nonmassive PE (n = 34) was 1304.7 ± 350.5 μg/L (p > 0.05). In Group 2, the mean D-dimer level of massive cases (n = 6) was 9.7 ± 2.2 mg/L and that of non-massive PE (n = 32) was 5.9 ± 1.3 mg/L (p < 0.05). The mean D-dimer levels of massive cases as measured with the immunoturbidimetric monoclonal antibody method were significantly higher. Pulmonary embolism patients whose D-dimer levels are higher (especially higher than 6.6 mg/L) should be considered as possibly having massive embolism. Diagnostic procedures and management can be planned according to this finding.</p> |
topic |
D-dimer massive pulmonary embolism pulmonary embolism |
url |
http://www.mrmjournal.com/content/5/3/168 |
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