Reduced gray matter volume and respiratory dysfunction in Parkinson’s disease: a voxel-based morphometry study
Abstract Background The respiratory dysfunction of patients with Parkinson’s disease (PD) has drawn increasing attention. This study evaluated the relationship between gray matter volume (GMV), as determined by voxel-based morphometry (VBM), and respiratory dysfunction in patients with PD and correl...
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doaj-5b5e3e59ee6e4ad7ab951d03e8e4e5612020-11-25T02:34:01ZengBMCBMC Neurology1471-23772018-05-011811810.1186/s12883-018-1074-8Reduced gray matter volume and respiratory dysfunction in Parkinson’s disease: a voxel-based morphometry studySieh-Yang Lee0Meng-Hsiang Chen1Pi-Ling Chiang2Hsiu-Ling Chen3Kun-Hsien Chou4Yueh-Cheng Chen5Chiun-Chieh Yu6Nai-Wen Tsai7Shau-Hsuan Li8Cheng-Hsien Lu9Wei-Che Lin10Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineBrain Research Center, National Yang-Ming UniversityDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineDepartment of Neurology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineDepartment of Oncology and Hematology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineDepartment of Neurology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineAbstract Background The respiratory dysfunction of patients with Parkinson’s disease (PD) has drawn increasing attention. This study evaluated the relationship between gray matter volume (GMV), as determined by voxel-based morphometry (VBM), and respiratory dysfunction in patients with PD and correlated it with systemic inflammatory markers. Methods Whole-brain VBM analysis was performed on 3-dimensional T1-weighted images in 25 PD patients with abnormal pulmonary function (13 men, 12 women; mean age: 62.9 ± 10.8 years) and, for comparison, on 25 sex- and age-matched PD patients with normal pulmonary function (14 men, 11 women; mean age: 62.3 ± 6.9 years). Inflammatory markers were determined by flow cytometry. The differences and correlations in regional GMV, clinical severity and inflammatory markers were determined after adjusting for age, gender and total intracranial volume (TIV). Results Compared with the normal pulmonary function group, the abnormal pulmonary function group had smaller GMV in several brain regions, including the left parahippocampal formation, right fusiform gyrus, right cerebellum crus, and left postcentral gyri. Forced expiratory volume in 1 s (FEV1) and maximal expiratory flow after expiration of 50% of forced vital capacity (MEF50) were positively correlated with regional GMV. There were no significant differences in the level of serum inflammatory markers between two groups. Conclusion Our findings suggested that involvement of the central autonomic network and GM loss may underlie the respiratory dysfunction in PD patients.http://link.springer.com/article/10.1186/s12883-018-1074-8Parkinson’s diseaseMagnetic resonance imagingGray matterRespiratory systemAutonomic nervous system |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sieh-Yang Lee Meng-Hsiang Chen Pi-Ling Chiang Hsiu-Ling Chen Kun-Hsien Chou Yueh-Cheng Chen Chiun-Chieh Yu Nai-Wen Tsai Shau-Hsuan Li Cheng-Hsien Lu Wei-Che Lin |
spellingShingle |
Sieh-Yang Lee Meng-Hsiang Chen Pi-Ling Chiang Hsiu-Ling Chen Kun-Hsien Chou Yueh-Cheng Chen Chiun-Chieh Yu Nai-Wen Tsai Shau-Hsuan Li Cheng-Hsien Lu Wei-Che Lin Reduced gray matter volume and respiratory dysfunction in Parkinson’s disease: a voxel-based morphometry study BMC Neurology Parkinson’s disease Magnetic resonance imaging Gray matter Respiratory system Autonomic nervous system |
author_facet |
Sieh-Yang Lee Meng-Hsiang Chen Pi-Ling Chiang Hsiu-Ling Chen Kun-Hsien Chou Yueh-Cheng Chen Chiun-Chieh Yu Nai-Wen Tsai Shau-Hsuan Li Cheng-Hsien Lu Wei-Che Lin |
author_sort |
Sieh-Yang Lee |
title |
Reduced gray matter volume and respiratory dysfunction in Parkinson’s disease: a voxel-based morphometry study |
title_short |
Reduced gray matter volume and respiratory dysfunction in Parkinson’s disease: a voxel-based morphometry study |
title_full |
Reduced gray matter volume and respiratory dysfunction in Parkinson’s disease: a voxel-based morphometry study |
title_fullStr |
Reduced gray matter volume and respiratory dysfunction in Parkinson’s disease: a voxel-based morphometry study |
title_full_unstemmed |
Reduced gray matter volume and respiratory dysfunction in Parkinson’s disease: a voxel-based morphometry study |
title_sort |
reduced gray matter volume and respiratory dysfunction in parkinson’s disease: a voxel-based morphometry study |
publisher |
BMC |
series |
BMC Neurology |
issn |
1471-2377 |
publishDate |
2018-05-01 |
description |
Abstract Background The respiratory dysfunction of patients with Parkinson’s disease (PD) has drawn increasing attention. This study evaluated the relationship between gray matter volume (GMV), as determined by voxel-based morphometry (VBM), and respiratory dysfunction in patients with PD and correlated it with systemic inflammatory markers. Methods Whole-brain VBM analysis was performed on 3-dimensional T1-weighted images in 25 PD patients with abnormal pulmonary function (13 men, 12 women; mean age: 62.9 ± 10.8 years) and, for comparison, on 25 sex- and age-matched PD patients with normal pulmonary function (14 men, 11 women; mean age: 62.3 ± 6.9 years). Inflammatory markers were determined by flow cytometry. The differences and correlations in regional GMV, clinical severity and inflammatory markers were determined after adjusting for age, gender and total intracranial volume (TIV). Results Compared with the normal pulmonary function group, the abnormal pulmonary function group had smaller GMV in several brain regions, including the left parahippocampal formation, right fusiform gyrus, right cerebellum crus, and left postcentral gyri. Forced expiratory volume in 1 s (FEV1) and maximal expiratory flow after expiration of 50% of forced vital capacity (MEF50) were positively correlated with regional GMV. There were no significant differences in the level of serum inflammatory markers between two groups. Conclusion Our findings suggested that involvement of the central autonomic network and GM loss may underlie the respiratory dysfunction in PD patients. |
topic |
Parkinson’s disease Magnetic resonance imaging Gray matter Respiratory system Autonomic nervous system |
url |
http://link.springer.com/article/10.1186/s12883-018-1074-8 |
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