Comparison of autocross-linked hyaluronic acid gel and intrauterine device for preventing intrauterine adhesions in infertile patients: A randomized clinical trial
Objectives: The objective of this study is to evaluate the efficacy of autocross-linked hyaluronic acid (HA) compared with intrauterine device (IUD) for preventing intrauterine adhesions (IUAs) in infertile patients after hysteroscopic adhesiolysis. Materials and Methods: A randomized clinical trial...
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Wolters Kluwer Medknow Publications
2020-01-01
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Series: | Gynecology and Minimally Invasive Therapy |
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doaj-5b7058b0609547edb8cd609d344505682020-11-25T03:36:06ZengWolters Kluwer Medknow PublicationsGynecology and Minimally Invasive Therapy2213-30702020-01-0192748010.4103/GMIT.GMIT_103_19Comparison of autocross-linked hyaluronic acid gel and intrauterine device for preventing intrauterine adhesions in infertile patients: A randomized clinical trialYu- Qing WangXiao- Hua SongShe- Ling WuYu- Zhen HuangLei YanChang-Zhong LiObjectives: The objective of this study is to evaluate the efficacy of autocross-linked hyaluronic acid (HA) compared with intrauterine device (IUD) for preventing intrauterine adhesions (IUAs) in infertile patients after hysteroscopic adhesiolysis. Materials and Methods: A randomized clinical trial (ChiCTR-IOR-16007746). Upon completion of adhesiolysis, 3 ml of HA gel was placed into the uterine cavity in Group A; 3 ml of HA gel and an IUD were placed in Group B; and only an IUD was placed in Group C. A second hysteroscopic examination was performed in all patients at approximately 1 month postoperatively for the evaluation of IUA. The primary outcome measure was the effective rate of IUA prevention based on the American Fertility Society (AFS) scoring system. Results: Eighty-nine women were randomly distributed into two groups for intention to treat with 30 patients in Group A, 24 patients in Group B, and 35 patients in Group C. Patients were scored and stratified into three degrees and were enrolled using the simple random sampling method. The three groups were well balanced. There were no significant differences in age, endometrial thickness, the previous number of pregnancy, and the distribution of adhesion categories across mild, moderate, and severe between the three groups. The effective rate of IUA prevention, the AFS score after therapy, and the percentage improvements of Chinese score and AFS score before and after surgery were statistically significant difference between Groups A and C. The clinical pregnancy rate in Group A was higher than those in Groups B and C, but the difference was not statistically significant. Conclusion: HA gel has an advantage over an IUD in reducing IUA recurrence and decreasing adhesions.http://www.e-gmit.com/article.asp?issn=2213-3070;year=2020;volume=9;issue=2;spage=74;epage=80;aulast=Wanghyaluronic acidhysteroscopyintrauterine adhesions |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yu- Qing Wang Xiao- Hua Song She- Ling Wu Yu- Zhen Huang Lei Yan Chang-Zhong Li |
spellingShingle |
Yu- Qing Wang Xiao- Hua Song She- Ling Wu Yu- Zhen Huang Lei Yan Chang-Zhong Li Comparison of autocross-linked hyaluronic acid gel and intrauterine device for preventing intrauterine adhesions in infertile patients: A randomized clinical trial Gynecology and Minimally Invasive Therapy hyaluronic acid hysteroscopy intrauterine adhesions |
author_facet |
Yu- Qing Wang Xiao- Hua Song She- Ling Wu Yu- Zhen Huang Lei Yan Chang-Zhong Li |
author_sort |
Yu- Qing Wang |
title |
Comparison of autocross-linked hyaluronic acid gel and intrauterine device for preventing intrauterine adhesions in infertile patients: A randomized clinical trial |
title_short |
Comparison of autocross-linked hyaluronic acid gel and intrauterine device for preventing intrauterine adhesions in infertile patients: A randomized clinical trial |
title_full |
Comparison of autocross-linked hyaluronic acid gel and intrauterine device for preventing intrauterine adhesions in infertile patients: A randomized clinical trial |
title_fullStr |
Comparison of autocross-linked hyaluronic acid gel and intrauterine device for preventing intrauterine adhesions in infertile patients: A randomized clinical trial |
title_full_unstemmed |
Comparison of autocross-linked hyaluronic acid gel and intrauterine device for preventing intrauterine adhesions in infertile patients: A randomized clinical trial |
title_sort |
comparison of autocross-linked hyaluronic acid gel and intrauterine device for preventing intrauterine adhesions in infertile patients: a randomized clinical trial |
publisher |
Wolters Kluwer Medknow Publications |
series |
Gynecology and Minimally Invasive Therapy |
issn |
2213-3070 |
publishDate |
2020-01-01 |
description |
Objectives: The objective of this study is to evaluate the efficacy of autocross-linked hyaluronic acid (HA) compared with intrauterine device (IUD) for preventing intrauterine adhesions (IUAs) in infertile patients after hysteroscopic adhesiolysis.
Materials and Methods: A randomized clinical trial (ChiCTR-IOR-16007746). Upon completion of adhesiolysis, 3 ml of HA gel was placed into the uterine cavity in Group A; 3 ml of HA gel and an IUD were placed in Group B; and only an IUD was placed in Group C. A second hysteroscopic examination was performed in all patients at approximately 1 month postoperatively for the evaluation of IUA. The primary outcome measure was the effective rate of IUA prevention based on the American Fertility Society (AFS) scoring system.
Results: Eighty-nine women were randomly distributed into two groups for intention to treat with 30 patients in Group A, 24 patients in Group B, and 35 patients in Group C. Patients were scored and stratified into three degrees and were enrolled using the simple random sampling method. The three groups were well balanced. There were no significant differences in age, endometrial thickness, the previous number of pregnancy, and the distribution of adhesion categories across mild, moderate, and severe between the three groups. The effective rate of IUA prevention, the AFS score after therapy, and the percentage improvements of Chinese score and AFS score before and after surgery were statistically significant difference between Groups A and C. The clinical pregnancy rate in Group A was higher than those in Groups B and C, but the difference was not statistically significant.
Conclusion: HA gel has an advantage over an IUD in reducing IUA recurrence and decreasing adhesions. |
topic |
hyaluronic acid hysteroscopy intrauterine adhesions |
url |
http://www.e-gmit.com/article.asp?issn=2213-3070;year=2020;volume=9;issue=2;spage=74;epage=80;aulast=Wang |
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