Serum Metabolomic Response to Long-Term Supplementation with all-rac-α-Tocopheryl Acetate in a Randomized Controlled Trial
Background. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study, a randomized controlled cancer prevention trial, showed a 32% reduction in prostate cancer incidence in response to vitamin E supplementation. Two other trials were not confirmatory, however. Objective. We compared the c...
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doaj-5b71ca82ac854deb9d7bf7dec2567ad62020-11-24T22:56:06ZengHindawi LimitedJournal of Nutrition and Metabolism2090-07242090-07322016-01-01201610.1155/2016/61584366158436Serum Metabolomic Response to Long-Term Supplementation with all-rac-α-Tocopheryl Acetate in a Randomized Controlled TrialAlison M. Mondul0Steven C. Moore1Stephanie J. Weinstein2Anne M. Evans3Edward D. Karoly4Satu Männistö5Joshua N. Sampson6Demetrius Albanes7Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USADepartment of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Nutritional Epidemiology Branch, Bethesda, MD, USADepartment of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Nutritional Epidemiology Branch, Bethesda, MD, USAMetabolon, Inc., Durham, NC, USAMetabolon, Inc., Durham, NC, USADepartment of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, FinlandDepartment of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Biostatistics Branch, Bethesda, MD, USADepartment of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Nutritional Epidemiology Branch, Bethesda, MD, USABackground. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study, a randomized controlled cancer prevention trial, showed a 32% reduction in prostate cancer incidence in response to vitamin E supplementation. Two other trials were not confirmatory, however. Objective. We compared the change in serum metabolome of the ATBC Study participants randomized to receive vitamin E to those who were not by randomly selecting 50 men from each of the intervention groups (50 mg/day all-rac-α-tocopheryl acetate (ATA), 20 mg/day β-carotene, both, placebo). Methods. Metabolomic profiling was conducted on baseline and follow-up fasting serum (Metabolon, Inc.). Results. After correction for multiple comparisons, five metabolites were statistically significantly altered (β is the change in metabolite level expressed as number of standard deviations on the log scale): α-CEHC sulfate (β=1.51, p=1.45×10-38), α-CEHC glucuronide (β=1.41, p=1.02×10-31), α-tocopherol (β=0.97, p=2.22×10-13), γ-tocopherol (β=-0.90, p=1.76×10-11), and β-tocopherol (β=-0.73, p=9.40×10-8). Glutarylcarnitine, beta-alanine, ornithine, and N6-acetyllysine were also decreased by ATA supplementation (β range 0.40 to −0.36), but not statistically significantly. Conclusions. Comparison of the observed metabolite alterations resulting from ATA supplementation to those in other vitamin E trials of different populations, dosages, or formulations may shed light on the apparently discordant vitamin E-prostate cancer risk findings.http://dx.doi.org/10.1155/2016/6158436 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alison M. Mondul Steven C. Moore Stephanie J. Weinstein Anne M. Evans Edward D. Karoly Satu Männistö Joshua N. Sampson Demetrius Albanes |
spellingShingle |
Alison M. Mondul Steven C. Moore Stephanie J. Weinstein Anne M. Evans Edward D. Karoly Satu Männistö Joshua N. Sampson Demetrius Albanes Serum Metabolomic Response to Long-Term Supplementation with all-rac-α-Tocopheryl Acetate in a Randomized Controlled Trial Journal of Nutrition and Metabolism |
author_facet |
Alison M. Mondul Steven C. Moore Stephanie J. Weinstein Anne M. Evans Edward D. Karoly Satu Männistö Joshua N. Sampson Demetrius Albanes |
author_sort |
Alison M. Mondul |
title |
Serum Metabolomic Response to Long-Term Supplementation with all-rac-α-Tocopheryl Acetate in a Randomized Controlled Trial |
title_short |
Serum Metabolomic Response to Long-Term Supplementation with all-rac-α-Tocopheryl Acetate in a Randomized Controlled Trial |
title_full |
Serum Metabolomic Response to Long-Term Supplementation with all-rac-α-Tocopheryl Acetate in a Randomized Controlled Trial |
title_fullStr |
Serum Metabolomic Response to Long-Term Supplementation with all-rac-α-Tocopheryl Acetate in a Randomized Controlled Trial |
title_full_unstemmed |
Serum Metabolomic Response to Long-Term Supplementation with all-rac-α-Tocopheryl Acetate in a Randomized Controlled Trial |
title_sort |
serum metabolomic response to long-term supplementation with all-rac-α-tocopheryl acetate in a randomized controlled trial |
publisher |
Hindawi Limited |
series |
Journal of Nutrition and Metabolism |
issn |
2090-0724 2090-0732 |
publishDate |
2016-01-01 |
description |
Background. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study, a randomized controlled cancer prevention trial, showed a 32% reduction in prostate cancer incidence in response to vitamin E supplementation. Two other trials were not confirmatory, however. Objective. We compared the change in serum metabolome of the ATBC Study participants randomized to receive vitamin E to those who were not by randomly selecting 50 men from each of the intervention groups (50 mg/day all-rac-α-tocopheryl acetate (ATA), 20 mg/day β-carotene, both, placebo). Methods. Metabolomic profiling was conducted on baseline and follow-up fasting serum (Metabolon, Inc.). Results. After correction for multiple comparisons, five metabolites were statistically significantly altered (β is the change in metabolite level expressed as number of standard deviations on the log scale): α-CEHC sulfate (β=1.51, p=1.45×10-38), α-CEHC glucuronide (β=1.41, p=1.02×10-31), α-tocopherol (β=0.97, p=2.22×10-13), γ-tocopherol (β=-0.90, p=1.76×10-11), and β-tocopherol (β=-0.73, p=9.40×10-8). Glutarylcarnitine, beta-alanine, ornithine, and N6-acetyllysine were also decreased by ATA supplementation (β range 0.40 to −0.36), but not statistically significantly. Conclusions. Comparison of the observed metabolite alterations resulting from ATA supplementation to those in other vitamin E trials of different populations, dosages, or formulations may shed light on the apparently discordant vitamin E-prostate cancer risk findings. |
url |
http://dx.doi.org/10.1155/2016/6158436 |
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