Type I interferon underlies severe disease associated with Junín virus infection in mice

Type I interferon underlies severe disease associated with Junín virus infection in mice

Junín virus (JUNV) is one of five New World mammarenaviruses (NWMs) that causes fatal hemorrhagic disease in humans and is the etiological agent of Argentine hemorrhagic fever (AHF). The pathogenesis underlying AHF is poorly understood; however, a prolonged, elevated interferon-α (IFN-α) response is...

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Bibliographic Details
Main Authors: Brady T Hickerson, Eric J Sefing, Kevin W Bailey, Arnaud J Van Wettere, Manuel L Penichet, Brian B Gowen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-05-01
Series:eLife
Subjects:
mammarenavirus
arenavirus
junin virus
transferrin receptor
interferon
viral hemorrhagic fever
Online Access:https://elifesciences.org/articles/55352

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