210Po microsphere radiological design for tumor vascular disruption

210Po microsphere radiological design for tumor vascular disruption

The feasibility of disrupting a tumor’s vascular structure using 210Po microspheres is investigated using standard ion and photon absorbed dose methodologies. Calculated absorbed dose profiles for 210Po alpha particles are sufficient to disrupt a tumor’s arteriole structure while minimizing the dose...

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Bibliographic Details
Main Author: JJ Bevelacqua
Format: Article
Language:English
Published: PeerJ Inc. 2015-08-01
Series:PeerJ
Subjects:
Absorbed dose
Dose assessment
Tumor vascular disruption
Radiation therapy
Microspheres
Online Access:https://peerj.com/articles/1143.pdf
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spelling doaj-5b7ebcdec6c34323aabc1f02f3a27ad02020-11-24T22:04:48ZengPeerJ Inc.PeerJ2167-83592015-08-013e114310.7717/peerj.1143210Po microsphere radiological design for tumor vascular disruptionJJ Bevelacqua0Bevelacqua Resources, Richland, WA, USAThe feasibility of disrupting a tumor’s vascular structure using 210Po microspheres is investigated using standard ion and photon absorbed dose methodologies. Calculated absorbed dose profiles for 210Po alpha particles are sufficient to disrupt a tumor’s arteriole structure while minimizing the dose outside the blood vessel wall. 210Po photons contribute minimal dose to healthy tissue. The requisite activity of 210Po to facilitate vascular disruption is calculated.https://peerj.com/articles/1143.pdfAbsorbed doseDose assessmentTumor vascular disruptionRadiation therapyMicrospheres
collection DOAJ
language English
format Article
sources DOAJ
author JJ Bevelacqua
spellingShingle JJ Bevelacqua
210Po microsphere radiological design for tumor vascular disruption
PeerJ
Absorbed dose
Dose assessment
Tumor vascular disruption
Radiation therapy
Microspheres
author_facet JJ Bevelacqua
author_sort JJ Bevelacqua
title 210Po microsphere radiological design for tumor vascular disruption
title_short 210Po microsphere radiological design for tumor vascular disruption
title_full 210Po microsphere radiological design for tumor vascular disruption
title_fullStr 210Po microsphere radiological design for tumor vascular disruption
title_full_unstemmed 210Po microsphere radiological design for tumor vascular disruption
title_sort 210po microsphere radiological design for tumor vascular disruption
publisher PeerJ Inc.
series PeerJ
issn 2167-8359
publishDate 2015-08-01
description The feasibility of disrupting a tumor’s vascular structure using 210Po microspheres is investigated using standard ion and photon absorbed dose methodologies. Calculated absorbed dose profiles for 210Po alpha particles are sufficient to disrupt a tumor’s arteriole structure while minimizing the dose outside the blood vessel wall. 210Po photons contribute minimal dose to healthy tissue. The requisite activity of 210Po to facilitate vascular disruption is calculated.
topic Absorbed dose
Dose assessment
Tumor vascular disruption
Radiation therapy
Microspheres
url https://peerj.com/articles/1143.pdf
work_keys_str_mv AT jjbevelacqua 210pomicrosphereradiologicaldesignfortumorvasculardisruption
_version_ 1725828715598839808

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