Potential of anti-inflammatory treatment for cystic fibrosis lung disease
Jennifer L Taylor-Cousar1,2, Kelsey A Von Kessel2, Robert Young1, David P Nichols1,21Department of Medicine, National Jewish Health, Denver, Colorado, USA; 2Department of Pediatrics, National Jewish Health, Denver, Colorado, USAAbstract: Cystic fibrosis (CF) is the most common life-shortening geneti...
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doaj-5baa09982483470f853a717619a5227a2020-11-25T00:25:38ZengDove Medical PressJournal of Inflammation Research1178-70312010-08-012010default6174Potential of anti-inflammatory treatment for cystic fibrosis lung diseaseJennifer L Taylor-CousarKelsey A Von KesselRobert Younget alJennifer L Taylor-Cousar1,2, Kelsey A Von Kessel2, Robert Young1, David P Nichols1,21Department of Medicine, National Jewish Health, Denver, Colorado, USA; 2Department of Pediatrics, National Jewish Health, Denver, Colorado, USAAbstract: Cystic fibrosis (CF) is the most common life-shortening genetic disorder in ­Caucasians. With improved diagnosis and treatment, survival has steadily increased. ­Unfortunately, the overwhelming majority of patients still die from respiratory failure caused by structural damage resulting from airway obstruction, recurrent infection, and inflammation. Here, we discuss the role of inflammation and the development of anti-inflammatory therapies to treat CF lung disease. The inflammatory host response is the least addressed component of CF airway disease at this time. Current challenges in both preclinical and clinical investigation make the identification of suitable anti-inflammatory drugs more difficult. Despite this, many researchers are making significant progress toward this goal and the CF research community has reason to believe that new therapies will emerge from these efforts.Keywords: therapy, cystic fibrosis, survival, inflammation http://www.dovepress.com/potential-of-anti-inflammatory-treatment-for-cystic-fibrosis-lung-dise-a5006 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jennifer L Taylor-Cousar Kelsey A Von Kessel Robert Young et al |
spellingShingle |
Jennifer L Taylor-Cousar Kelsey A Von Kessel Robert Young et al Potential of anti-inflammatory treatment for cystic fibrosis lung disease Journal of Inflammation Research |
author_facet |
Jennifer L Taylor-Cousar Kelsey A Von Kessel Robert Young et al |
author_sort |
Jennifer L Taylor-Cousar |
title |
Potential of anti-inflammatory treatment for cystic fibrosis lung disease |
title_short |
Potential of anti-inflammatory treatment for cystic fibrosis lung disease |
title_full |
Potential of anti-inflammatory treatment for cystic fibrosis lung disease |
title_fullStr |
Potential of anti-inflammatory treatment for cystic fibrosis lung disease |
title_full_unstemmed |
Potential of anti-inflammatory treatment for cystic fibrosis lung disease |
title_sort |
potential of anti-inflammatory treatment for cystic fibrosis lung disease |
publisher |
Dove Medical Press |
series |
Journal of Inflammation Research |
issn |
1178-7031 |
publishDate |
2010-08-01 |
description |
Jennifer L Taylor-Cousar1,2, Kelsey A Von Kessel2, Robert Young1, David P Nichols1,21Department of Medicine, National Jewish Health, Denver, Colorado, USA; 2Department of Pediatrics, National Jewish Health, Denver, Colorado, USAAbstract: Cystic fibrosis (CF) is the most common life-shortening genetic disorder in ­Caucasians. With improved diagnosis and treatment, survival has steadily increased. ­Unfortunately, the overwhelming majority of patients still die from respiratory failure caused by structural damage resulting from airway obstruction, recurrent infection, and inflammation. Here, we discuss the role of inflammation and the development of anti-inflammatory therapies to treat CF lung disease. The inflammatory host response is the least addressed component of CF airway disease at this time. Current challenges in both preclinical and clinical investigation make the identification of suitable anti-inflammatory drugs more difficult. Despite this, many researchers are making significant progress toward this goal and the CF research community has reason to believe that new therapies will emerge from these efforts.Keywords: therapy, cystic fibrosis, survival, inflammation |
url |
http://www.dovepress.com/potential-of-anti-inflammatory-treatment-for-cystic-fibrosis-lung-dise-a5006 |
work_keys_str_mv |
AT jenniferltaylorcousar potentialofantiinflammatorytreatmentforcysticfibrosislungdisease AT kelseyavonkessel potentialofantiinflammatorytreatmentforcysticfibrosislungdisease AT robertyoung potentialofantiinflammatorytreatmentforcysticfibrosislungdisease AT etal potentialofantiinflammatorytreatmentforcysticfibrosislungdisease |
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