Telomerase Inhibition by a New Synthetic Derivative of the Aporphine Alkaloid Boldine

Telomerase Inhibition by a New Synthetic Derivative of the Aporphine Alkaloid Boldine

Telomerase, the enzyme responsible for cell immortality, is an important target in anti-cancer drug discovery. Boldine, an abundant aporphine alkaloid of Peumus boldus, is known to inhibit telomerase at non-toxic concentrations. Cytotoxicity of N-benzylsecoboldine hydrochloride (BSB), a synthetic de...

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Bibliographic Details
Main Authors: Sakineh Kazemi Noureini, Mitra Kheirabadi, Fatima Masoumi, Farve Khosrogerdi, Younes Zarei, Cristian Suárez-Rozas, Julio Salas-Norambuena, Bruce Kennedy Cassels
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:International Journal of Molecular Sciences
Subjects:
telomerase inhibition
boldine
N-benzylsecoboldine
derivative
binding site
Online Access:http://www.mdpi.com/1422-0067/19/4/1239

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