Resected thymic large cell neuroendocrine carcinoma: report of a case
Abstract Background Thymic large cell neuroendocrine carcinoma (LCNEC) is extremely rare. The detailed clinical features of thymic LNCECs remain unknown. Case presentation A 90-year-old man with a history of diabetes mellitus, chronic renal failure, and an abdominal aortic aneurysm underwent compute...
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doaj-5bb65bb4ff10472a8da68a433909509c2020-11-25T01:32:26ZengSpringerOpenSurgical Case Reports2198-77932018-11-01411610.1186/s40792-018-0540-2Resected thymic large cell neuroendocrine carcinoma: report of a caseHiromitsu Domen0Yasuhiro Hida1Masaaki Sato2Haruka Takahashi3Tatsuru Ishikawa4Yosuke Shionoya5Midori Hashimoto6Kaoru Nishiyama7Yuma Aoki8Kazuho Inoko9Syotaro Furukawa10Kazuomi Ichinokawa11Hidehisa Yamada12Department of Surgery, Nippon Telegraph and Telephone East Corporation Sapporo Medical CenterDepartment of Cardiovascular and Thoracic Surgery, Faculty of Medicine, Hokkaido UniversityDepartment of Pathology, Nippon Telegraph and Telephone East Corporation Sapporo Medical CenterDepartment of Respiratory Medicine, Nippon Telegraph and Telephone East Corporation Sapporo Medical CenterDepartment of Respiratory Medicine, Nippon Telegraph and Telephone East Corporation Sapporo Medical CenterDepartment of Respiratory Medicine, Nippon Telegraph and Telephone East Corporation Sapporo Medical CenterDepartment of Respiratory Medicine, Nippon Telegraph and Telephone East Corporation Sapporo Medical CenterDepartment of Respiratory Medicine, Nippon Telegraph and Telephone East Corporation Sapporo Medical CenterDepartment of Surgery, Nippon Telegraph and Telephone East Corporation Sapporo Medical CenterDepartment of Surgery, Nippon Telegraph and Telephone East Corporation Sapporo Medical CenterDepartment of Surgery, Nippon Telegraph and Telephone East Corporation Sapporo Medical CenterDepartment of Surgery, Nippon Telegraph and Telephone East Corporation Sapporo Medical CenterDepartment of Surgery, Nippon Telegraph and Telephone East Corporation Sapporo Medical CenterAbstract Background Thymic large cell neuroendocrine carcinoma (LCNEC) is extremely rare. The detailed clinical features of thymic LNCECs remain unknown. Case presentation A 90-year-old man with a history of diabetes mellitus, chronic renal failure, and an abdominal aortic aneurysm underwent computed tomography for follow-up, which showed an anterior mediastinal tumor, measuring 31 mm × 28 mm in diameter. Magnetic resonance imaging showed an iso-intensity mass on T1-weighted images and high intensity on T2-weighted images. 18F-Fluorodeoxyglucose-positron emission tomography showed marked uptake in the mass, which was diagnosed as invasive thymoma or thymic carcinoma. Video-assisted thoracic surgery through the left thoracic cavity was converted to median sternotomy due to severe adhesions between the left lung and the chest wall. Partial thymectomy and combined partial resection of left upper lobectomy and the first and the second costal cartilages were performed. The pathologic diagnosis was thymic LCNEC, Masaoka stage III. The patient developed pleural dissemination and left lung metastases in 5 months and died 12 months after surgery. Conclusions Thymic LCNEC has high malignant potential. More cases need to be studied.http://link.springer.com/article/10.1186/s40792-018-0540-2Large cell neuroendocrine carcinomaThymusSurgeryLCNECThymic LCNEC |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hiromitsu Domen Yasuhiro Hida Masaaki Sato Haruka Takahashi Tatsuru Ishikawa Yosuke Shionoya Midori Hashimoto Kaoru Nishiyama Yuma Aoki Kazuho Inoko Syotaro Furukawa Kazuomi Ichinokawa Hidehisa Yamada |
spellingShingle |
Hiromitsu Domen Yasuhiro Hida Masaaki Sato Haruka Takahashi Tatsuru Ishikawa Yosuke Shionoya Midori Hashimoto Kaoru Nishiyama Yuma Aoki Kazuho Inoko Syotaro Furukawa Kazuomi Ichinokawa Hidehisa Yamada Resected thymic large cell neuroendocrine carcinoma: report of a case Surgical Case Reports Large cell neuroendocrine carcinoma Thymus Surgery LCNEC Thymic LCNEC |
author_facet |
Hiromitsu Domen Yasuhiro Hida Masaaki Sato Haruka Takahashi Tatsuru Ishikawa Yosuke Shionoya Midori Hashimoto Kaoru Nishiyama Yuma Aoki Kazuho Inoko Syotaro Furukawa Kazuomi Ichinokawa Hidehisa Yamada |
author_sort |
Hiromitsu Domen |
title |
Resected thymic large cell neuroendocrine carcinoma: report of a case |
title_short |
Resected thymic large cell neuroendocrine carcinoma: report of a case |
title_full |
Resected thymic large cell neuroendocrine carcinoma: report of a case |
title_fullStr |
Resected thymic large cell neuroendocrine carcinoma: report of a case |
title_full_unstemmed |
Resected thymic large cell neuroendocrine carcinoma: report of a case |
title_sort |
resected thymic large cell neuroendocrine carcinoma: report of a case |
publisher |
SpringerOpen |
series |
Surgical Case Reports |
issn |
2198-7793 |
publishDate |
2018-11-01 |
description |
Abstract Background Thymic large cell neuroendocrine carcinoma (LCNEC) is extremely rare. The detailed clinical features of thymic LNCECs remain unknown. Case presentation A 90-year-old man with a history of diabetes mellitus, chronic renal failure, and an abdominal aortic aneurysm underwent computed tomography for follow-up, which showed an anterior mediastinal tumor, measuring 31 mm × 28 mm in diameter. Magnetic resonance imaging showed an iso-intensity mass on T1-weighted images and high intensity on T2-weighted images. 18F-Fluorodeoxyglucose-positron emission tomography showed marked uptake in the mass, which was diagnosed as invasive thymoma or thymic carcinoma. Video-assisted thoracic surgery through the left thoracic cavity was converted to median sternotomy due to severe adhesions between the left lung and the chest wall. Partial thymectomy and combined partial resection of left upper lobectomy and the first and the second costal cartilages were performed. The pathologic diagnosis was thymic LCNEC, Masaoka stage III. The patient developed pleural dissemination and left lung metastases in 5 months and died 12 months after surgery. Conclusions Thymic LCNEC has high malignant potential. More cases need to be studied. |
topic |
Large cell neuroendocrine carcinoma Thymus Surgery LCNEC Thymic LCNEC |
url |
http://link.springer.com/article/10.1186/s40792-018-0540-2 |
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