MicroRNAs in Synovial Pathology Associated With Osteoarthritis

Osteoarthritis (OA) is the most common type of arthritis, a disease that affects the entire joint. The relative involvement of each tissue, and their interactions, add to the complexity of OA, hampering our understanding of the underlying molecular mechanisms, and the generation of a disease modifyi...

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Main Authors:	Ghazaleh Tavallaee, Jason S. Rockel, Starlee Lively, Mohit Kapoor
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-08-01
Series:	Frontiers in Medicine
Subjects:	osteoarthritis synovium microRNA inflammation fibrosis
Online Access:	https://www.frontiersin.org/article/10.3389/fmed.2020.00376/full

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spelling	doaj-5bba94a63ef147119dc0270a6d187bbb2020-11-25T02:58:23ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2020-08-01710.3389/fmed.2020.00376553202MicroRNAs in Synovial Pathology Associated With OsteoarthritisGhazaleh Tavallaee0Ghazaleh Tavallaee1Jason S. Rockel2Starlee Lively3Mohit Kapoor4Mohit Kapoor5Mohit Kapoor6Arthritis Program, Krembil Research Institute, University Health Network, Toronto, ON, CanadaDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, CanadaArthritis Program, Krembil Research Institute, University Health Network, Toronto, ON, CanadaArthritis Program, Krembil Research Institute, University Health Network, Toronto, ON, CanadaArthritis Program, Krembil Research Institute, University Health Network, Toronto, ON, CanadaDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, CanadaDepartment of Surgery, University of Toronto, Toronto, ON, CanadaOsteoarthritis (OA) is the most common type of arthritis, a disease that affects the entire joint. The relative involvement of each tissue, and their interactions, add to the complexity of OA, hampering our understanding of the underlying molecular mechanisms, and the generation of a disease modifying therapy. The synovium is essential in maintaining joint homeostasis, and pathologies associated with the synovium contribute to joint destruction, pain and stiffness in OA. MicroRNAs (miRNAs) are post-transcriptional regulators dysregulated in OA tissues including the synovium. MiRNAs are important contributors to OA synovial changes that have the potential to improve our understanding of OA and to act as novel therapeutic targets. The purpose of this review is to summarize and integrate current published literature investigating the roles that miRNAs play in OA-related synovial pathologies including inflammation, matrix deposition and cell proliferation.https://www.frontiersin.org/article/10.3389/fmed.2020.00376/fullosteoarthritissynoviummicroRNAinflammationfibrosis
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ghazaleh Tavallaee Ghazaleh Tavallaee Jason S. Rockel Starlee Lively Mohit Kapoor Mohit Kapoor Mohit Kapoor
spellingShingle	Ghazaleh Tavallaee Ghazaleh Tavallaee Jason S. Rockel Starlee Lively Mohit Kapoor Mohit Kapoor Mohit Kapoor MicroRNAs in Synovial Pathology Associated With Osteoarthritis Frontiers in Medicine osteoarthritis synovium microRNA inflammation fibrosis
author_facet	Ghazaleh Tavallaee Ghazaleh Tavallaee Jason S. Rockel Starlee Lively Mohit Kapoor Mohit Kapoor Mohit Kapoor
author_sort	Ghazaleh Tavallaee
title	MicroRNAs in Synovial Pathology Associated With Osteoarthritis
title_short	MicroRNAs in Synovial Pathology Associated With Osteoarthritis
title_full	MicroRNAs in Synovial Pathology Associated With Osteoarthritis
title_fullStr	MicroRNAs in Synovial Pathology Associated With Osteoarthritis
title_full_unstemmed	MicroRNAs in Synovial Pathology Associated With Osteoarthritis
title_sort	micrornas in synovial pathology associated with osteoarthritis
publisher	Frontiers Media S.A.
series	Frontiers in Medicine
issn	2296-858X
publishDate	2020-08-01
description	Osteoarthritis (OA) is the most common type of arthritis, a disease that affects the entire joint. The relative involvement of each tissue, and their interactions, add to the complexity of OA, hampering our understanding of the underlying molecular mechanisms, and the generation of a disease modifying therapy. The synovium is essential in maintaining joint homeostasis, and pathologies associated with the synovium contribute to joint destruction, pain and stiffness in OA. MicroRNAs (miRNAs) are post-transcriptional regulators dysregulated in OA tissues including the synovium. MiRNAs are important contributors to OA synovial changes that have the potential to improve our understanding of OA and to act as novel therapeutic targets. The purpose of this review is to summarize and integrate current published literature investigating the roles that miRNAs play in OA-related synovial pathologies including inflammation, matrix deposition and cell proliferation.
topic	osteoarthritis synovium microRNA inflammation fibrosis
url	https://www.frontiersin.org/article/10.3389/fmed.2020.00376/full
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MicroRNAs in Synovial Pathology Associated With Osteoarthritis

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