A Rare Case of Hypercalcemic Crisis Secondary to a Squamous Cell Carcinoma Arising from a Nonhealing Ulcer
ABSTRACT: Objective: To report a case of hypercalcemic crisis in an African American male who presented with a nonhealing ulcer which was later found to be squamous cell carcinoma.Methods: All relevant data, radiologic imaging, and pathology reports were reviewed in detail. An in-depth literature re...
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2017-01-01
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| Series: | AACE Clinical Case Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2376060520304193 |
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doaj-5bbf5c06f712414f9517cf475ca04c622021-04-30T07:24:36ZengElsevierAACE Clinical Case Reports2376-06052017-01-0134303306A Rare Case of Hypercalcemic Crisis Secondary to a Squamous Cell Carcinoma Arising from a Nonhealing UlcerMuhammad A. Saeed, MD0Geny Ann George, MD1Sigfred Lajara, MD2Bennal Perkins, MD3Colette M. Knight, MD4From the Department of Internal Medicine, Montefiore Medical Center, Bronx, New York.From the Department of Internal Medicine, Montefiore Medical Center, Bronx, New York.Department of Pathology, Montefiore Medical Center, Bronx, New York.From the Department of Internal Medicine, Montefiore Medical Center, Bronx, New York.From the Department of Internal Medicine, Montefiore Medical Center, Bronx, New York.; Division of Endocrinology, Montefiore Medical Center, Bronx, New York.; Address correspondence to Dr. Colette M. Knight, Department of Medicine, Division of Endocrinology, Montefiore Medical Center, Wakefield Campus, 600 East 233rd Street, Bronx, NY 10466.ABSTRACT: Objective: To report a case of hypercalcemic crisis in an African American male who presented with a nonhealing ulcer which was later found to be squamous cell carcinoma.Methods: All relevant data, radiologic imaging, and pathology reports were reviewed in detail. An in-depth literature review for humoral hypercalcemia of malignancy and cutaneous squamous cell carcinoma was performed using MEDLINE.Results: A 58-year-old man with a history of chronic lymphedema presented with fever and a nonhealing left foot ulcer. Initial studies revealed acute kidney injury, anemia, and non–parathyroid hormone (PTH)-mediated hypercalcemic crisis (calcium, 17.7 mg/dL). A thorough work-up ruled out bone metastasis and confirmed increased PTH-related peptide, which is the hallmark of humoral hypercalcemia of malignancy (HHM). Hypercalcemia was initially managed with intravenous fluid hydration, bisphosphonates, and calcitonin. The patient had surgical resection of the left leg, and pathology revealed cutaneous squamous cell carcinoma. Hypercalcemia resolved completely after surgical resection of the tumor.Conclusion: Clinicians should be aware of the possibility of HHM as a rare complication associated with squamous cell carcinoma arising from nonhealing ulcers.Abbreviations: HHM humeral hypercalcemia of malignancy; PTH parathyroid hormone; PTHrP parathyroid hormone–related peptide; SCC squamous cell carcinomahttp://www.sciencedirect.com/science/article/pii/S2376060520304193 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Muhammad A. Saeed, MD Geny Ann George, MD Sigfred Lajara, MD Bennal Perkins, MD Colette M. Knight, MD |
| spellingShingle |
Muhammad A. Saeed, MD Geny Ann George, MD Sigfred Lajara, MD Bennal Perkins, MD Colette M. Knight, MD A Rare Case of Hypercalcemic Crisis Secondary to a Squamous Cell Carcinoma Arising from a Nonhealing Ulcer AACE Clinical Case Reports |
| author_facet |
Muhammad A. Saeed, MD Geny Ann George, MD Sigfred Lajara, MD Bennal Perkins, MD Colette M. Knight, MD |
| author_sort |
Muhammad A. Saeed, MD |
| title |
A Rare Case of Hypercalcemic Crisis Secondary to a Squamous Cell Carcinoma Arising from a Nonhealing Ulcer |
| title_short |
A Rare Case of Hypercalcemic Crisis Secondary to a Squamous Cell Carcinoma Arising from a Nonhealing Ulcer |
| title_full |
A Rare Case of Hypercalcemic Crisis Secondary to a Squamous Cell Carcinoma Arising from a Nonhealing Ulcer |
| title_fullStr |
A Rare Case of Hypercalcemic Crisis Secondary to a Squamous Cell Carcinoma Arising from a Nonhealing Ulcer |
| title_full_unstemmed |
A Rare Case of Hypercalcemic Crisis Secondary to a Squamous Cell Carcinoma Arising from a Nonhealing Ulcer |
| title_sort |
rare case of hypercalcemic crisis secondary to a squamous cell carcinoma arising from a nonhealing ulcer |
| publisher |
Elsevier |
| series |
AACE Clinical Case Reports |
| issn |
2376-0605 |
| publishDate |
2017-01-01 |
| description |
ABSTRACT: Objective: To report a case of hypercalcemic crisis in an African American male who presented with a nonhealing ulcer which was later found to be squamous cell carcinoma.Methods: All relevant data, radiologic imaging, and pathology reports were reviewed in detail. An in-depth literature review for humoral hypercalcemia of malignancy and cutaneous squamous cell carcinoma was performed using MEDLINE.Results: A 58-year-old man with a history of chronic lymphedema presented with fever and a nonhealing left foot ulcer. Initial studies revealed acute kidney injury, anemia, and non–parathyroid hormone (PTH)-mediated hypercalcemic crisis (calcium, 17.7 mg/dL). A thorough work-up ruled out bone metastasis and confirmed increased PTH-related peptide, which is the hallmark of humoral hypercalcemia of malignancy (HHM). Hypercalcemia was initially managed with intravenous fluid hydration, bisphosphonates, and calcitonin. The patient had surgical resection of the left leg, and pathology revealed cutaneous squamous cell carcinoma. Hypercalcemia resolved completely after surgical resection of the tumor.Conclusion: Clinicians should be aware of the possibility of HHM as a rare complication associated with squamous cell carcinoma arising from nonhealing ulcers.Abbreviations: HHM humeral hypercalcemia of malignancy; PTH parathyroid hormone; PTHrP parathyroid hormone–related peptide; SCC squamous cell carcinoma |
| url |
http://www.sciencedirect.com/science/article/pii/S2376060520304193 |
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