Choroidal Thickness in Acute Non-arteritic Anterior Ischemic Optic Neuropathy
Purpose: To compare the choroidal thickness in eyes with acute non-arteritic anterior ischemic optic neuropathy (NAION) with healthy contralateral eye and normal controls. Methods: Thirty-eight eyes with NAION, thirty-eight unaffected fellow eyes, and seventy-four eyes from 37 healthy, age- an...
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doaj-5bc4c9b6b2d24ab18ce7a00adc1b9f2c2020-11-24T21:06:32ZengKnowledge EJournal of Ophthalmic & Vision Research2008-322X2020-02-0115596810.18502/jovr.v15i1.5946Choroidal Thickness in Acute Non-arteritic Anterior Ischemic Optic NeuropathyHomayoun Nikkhah0Mohadeseh Feizi1Naser Abedi2Saeed Karimi3Mehdi Yaseri4Hamed Esfandiari5Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, USADepartment of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, USADepartment of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, USADepartment of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, USADepartment of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, USADepartment of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, USAPurpose: To compare the choroidal thickness in eyes with acute non-arteritic anterior ischemic optic neuropathy (NAION) with healthy contralateral eye and normal controls. Methods: Thirty-eight eyes with NAION, thirty-eight unaffected fellow eyes, and seventy-four eyes from 37 healthy, age- and sex-matched subjects were included in this prospective comparative case-control study. Choroidal thickness was measured by enhanced depth imaging (EDI) of spectral domain optical coherence tomography (SD-OCT). Peripapillary choroidal thickness (PCT) was measured at 1000 and 1500 μ m from Bruch's membrane opening (BMO). Subfoveal choroidal thickness (SFCT) was measured in central subfoveal area, and 500 microns apart in temporal and nasal sides. Choroidal thickness among NAION eyes, uninvolved fellow eyes, and control eyes were compared. Results: The mean of PCT at 1000 μ m was significantly thicker in NAION and fellow eyes compared to control eyes (169.7 ± 47, 154.4 ± 42.1, and 127.7 ± 49.9 μ m, respectively, P < 0.001 and P = 0.42). The mean PCT at 1500 μ m was also significantly thicker in NAION and fellow eyes compared to control eyes (178.6 ± 52.8, 162.6 ± 46.1, and 135.1 ± 59 μ m, respectively, P = 0.007 and P = 0.048). The mean PCT at 1000 and 1500 μ m was significantly greater in NAION compared to fellow eyes (P = 0.027 and P = 0.035, respectively). The mean of SFCT was significantly thicker in NAION compared to control eyes (P = 0.032); however, there was no significant difference between uninvolved fellow and control eyes (P = 0.248). Conclusion: Thicker choroidal thickness in acute NAION and uninvolved fellow eyes compared to normal eyes suggests a primary choroidal role in NAION pathophysiology.https://doi.org/10.18502/jovr.v15i1.5946choroidal thicknessnon-arteritic ischemic optic neuropathyoptic nerve headswept source optical coherence tomography |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Homayoun Nikkhah Mohadeseh Feizi Naser Abedi Saeed Karimi Mehdi Yaseri Hamed Esfandiari |
spellingShingle |
Homayoun Nikkhah Mohadeseh Feizi Naser Abedi Saeed Karimi Mehdi Yaseri Hamed Esfandiari Choroidal Thickness in Acute Non-arteritic Anterior Ischemic Optic Neuropathy Journal of Ophthalmic & Vision Research choroidal thickness non-arteritic ischemic optic neuropathy optic nerve head swept source optical coherence tomography |
author_facet |
Homayoun Nikkhah Mohadeseh Feizi Naser Abedi Saeed Karimi Mehdi Yaseri Hamed Esfandiari |
author_sort |
Homayoun Nikkhah |
title |
Choroidal Thickness in Acute Non-arteritic Anterior Ischemic Optic Neuropathy |
title_short |
Choroidal Thickness in Acute Non-arteritic Anterior Ischemic Optic Neuropathy |
title_full |
Choroidal Thickness in Acute Non-arteritic Anterior Ischemic Optic Neuropathy |
title_fullStr |
Choroidal Thickness in Acute Non-arteritic Anterior Ischemic Optic Neuropathy |
title_full_unstemmed |
Choroidal Thickness in Acute Non-arteritic Anterior Ischemic Optic Neuropathy |
title_sort |
choroidal thickness in acute non-arteritic anterior ischemic optic neuropathy |
publisher |
Knowledge E |
series |
Journal of Ophthalmic & Vision Research |
issn |
2008-322X |
publishDate |
2020-02-01 |
description |
Purpose: To compare the choroidal thickness in eyes with acute non-arteritic anterior ischemic optic neuropathy (NAION) with healthy contralateral eye and normal controls.
Methods: Thirty-eight eyes with NAION, thirty-eight unaffected fellow eyes, and seventy-four eyes from 37 healthy, age- and sex-matched subjects were included in this prospective comparative case-control study. Choroidal thickness was measured by enhanced depth imaging (EDI) of spectral domain optical coherence tomography (SD-OCT). Peripapillary choroidal thickness (PCT) was measured at 1000 and 1500
μ
m from Bruch's membrane opening (BMO). Subfoveal choroidal thickness (SFCT) was measured in central subfoveal area, and 500 microns apart in temporal and nasal sides. Choroidal thickness among NAION eyes, uninvolved fellow eyes, and control eyes were compared.
Results: The mean of PCT at 1000
μ
m was significantly thicker in NAION and fellow eyes compared to control eyes (169.7
±
47, 154.4
±
42.1, and 127.7
±
49.9
μ
m, respectively, P
<
0.001 and P = 0.42). The mean PCT at 1500
μ
m was also significantly thicker in NAION and fellow eyes compared to control eyes (178.6
±
52.8, 162.6
±
46.1, and 135.1
±
59
μ
m, respectively, P = 0.007 and P = 0.048). The mean PCT at 1000 and 1500
μ
m was significantly greater in NAION compared to fellow eyes (P = 0.027 and P = 0.035, respectively). The mean of SFCT was significantly thicker in NAION compared to control eyes (P = 0.032); however, there was no significant difference between uninvolved fellow and control eyes (P = 0.248).
Conclusion: Thicker choroidal thickness in acute NAION and uninvolved fellow eyes compared to normal eyes suggests a primary choroidal role in NAION pathophysiology. |
topic |
choroidal thickness non-arteritic ischemic optic neuropathy optic nerve head swept source optical coherence tomography |
url |
https://doi.org/10.18502/jovr.v15i1.5946 |
work_keys_str_mv |
AT homayounnikkhah choroidalthicknessinacutenonarteriticanteriorischemicopticneuropathy AT mohadesehfeizi choroidalthicknessinacutenonarteriticanteriorischemicopticneuropathy AT naserabedi choroidalthicknessinacutenonarteriticanteriorischemicopticneuropathy AT saeedkarimi choroidalthicknessinacutenonarteriticanteriorischemicopticneuropathy AT mehdiyaseri choroidalthicknessinacutenonarteriticanteriorischemicopticneuropathy AT hamedesfandiari choroidalthicknessinacutenonarteriticanteriorischemicopticneuropathy |
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