The role of α-E-catenin in cerebral cortex development: radial glia specific effect on neuronal migration

The role of α-E-catenin in cerebral cortex development: radial glia specific effect on neuronal migration

During brain development, radial glial cells possess an apico-basal polarity and are coupled by adherens junctions to an F-actin belt. To elucidate the role of the actin, we conditionally deleted the key component α-E-catenin in the developing cerebral cortex. Deletion at early stages resulted in se...

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Bibliographic Details
Main Authors: Marie-Theres eSchmid, Franziska eWeinandy, Michaela eWilsch-Bräuninger, Wieland B eHuttner, Silvia eCappello, Magdalena eGötz
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Adherens Junctions
Cell Polarity
neuronal migration
Actin
α-E-catenin
subcortical band heterotopia
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00215/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00215/full

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