WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis

The regulation and coordination of F-actin networks are not well understood. Here, the authors show an antagonistic relationship between endosomal F-actin assembly and cortical bundle integrity during epithelial tube maturation that is regulated by kinase and phosphatase activity modifying WASH.

Bibliographic Details
Main Authors:	Vasilios Tsarouhas, Dan Liu, Georgia Tsikala, Alina Fedoseienko, Kai Zinn, Ryo Matsuda, Daniel D. Billadeau, Christos Samakovlis
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-10229-6

id	doaj-5be47f95eade47cbb57480612cb0e67d
record_format	Article
spelling	doaj-5be47f95eade47cbb57480612cb0e67d2021-05-11T12:23:14ZengNature Publishing GroupNature Communications2041-17232019-05-0110111610.1038/s41467-019-10229-6WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesisVasilios Tsarouhas0Dan Liu1Georgia Tsikala2Alina Fedoseienko3Kai Zinn4Ryo Matsuda5Daniel D. Billadeau6Christos Samakovlis7Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm UniversityDepartment of Molecular Biosciences, The Wenner-Gren Institute, Stockholm UniversityDepartment of Molecular Biosciences, The Wenner-Gren Institute, Stockholm UniversityDepartment of Biochemistry and Division of Oncology Research, College of Medicine, Mayo ClinicDivision of Biology and Biological Engineering, California Institute of TechnologyDepartment of Molecular Biosciences, The Wenner-Gren Institute, Stockholm UniversityDepartment of Biochemistry and Division of Oncology Research, College of Medicine, Mayo ClinicDepartment of Molecular Biosciences, The Wenner-Gren Institute, Stockholm UniversityThe regulation and coordination of F-actin networks are not well understood. Here, the authors show an antagonistic relationship between endosomal F-actin assembly and cortical bundle integrity during epithelial tube maturation that is regulated by kinase and phosphatase activity modifying WASH.https://doi.org/10.1038/s41467-019-10229-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Vasilios Tsarouhas Dan Liu Georgia Tsikala Alina Fedoseienko Kai Zinn Ryo Matsuda Daniel D. Billadeau Christos Samakovlis
spellingShingle	Vasilios Tsarouhas Dan Liu Georgia Tsikala Alina Fedoseienko Kai Zinn Ryo Matsuda Daniel D. Billadeau Christos Samakovlis WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis Nature Communications
author_facet	Vasilios Tsarouhas Dan Liu Georgia Tsikala Alina Fedoseienko Kai Zinn Ryo Matsuda Daniel D. Billadeau Christos Samakovlis
author_sort	Vasilios Tsarouhas
title	WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis
title_short	WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis
title_full	WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis
title_fullStr	WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis
title_full_unstemmed	WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis
title_sort	wash phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-05-01
description	The regulation and coordination of F-actin networks are not well understood. Here, the authors show an antagonistic relationship between endosomal F-actin assembly and cortical bundle integrity during epithelial tube maturation that is regulated by kinase and phosphatase activity modifying WASH.
url	https://doi.org/10.1038/s41467-019-10229-6
work_keys_str_mv	AT vasiliostsarouhas washphosphorylationbalancesendosomalversuscorticalactinnetworkintegritiesduringepithelialmorphogenesis AT danliu washphosphorylationbalancesendosomalversuscorticalactinnetworkintegritiesduringepithelialmorphogenesis AT georgiatsikala washphosphorylationbalancesendosomalversuscorticalactinnetworkintegritiesduringepithelialmorphogenesis AT alinafedoseienko washphosphorylationbalancesendosomalversuscorticalactinnetworkintegritiesduringepithelialmorphogenesis AT kaizinn washphosphorylationbalancesendosomalversuscorticalactinnetworkintegritiesduringepithelialmorphogenesis AT ryomatsuda washphosphorylationbalancesendosomalversuscorticalactinnetworkintegritiesduringepithelialmorphogenesis AT danieldbilladeau washphosphorylationbalancesendosomalversuscorticalactinnetworkintegritiesduringepithelialmorphogenesis AT christossamakovlis washphosphorylationbalancesendosomalversuscorticalactinnetworkintegritiesduringepithelialmorphogenesis
_version_	1721444919356162048

WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis

Similar Items