WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis
The regulation and coordination of F-actin networks are not well understood. Here, the authors show an antagonistic relationship between endosomal F-actin assembly and cortical bundle integrity during epithelial tube maturation that is regulated by kinase and phosphatase activity modifying WASH.
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-05-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10229-6 |