Does the expression of the ACVR2A gene affect the development of colorectal cancer?

• Main Authors: Damian Wodziński, Agnieszka Wosiak, Jacek Pietrzak, Rafał Świechowski, Agnieszka Jeleń, Ewa Balcerczak
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Genética 2019-03-01
• Series: Genetics and Molecular Biology
• Subjects: Activin A protein; ACVR2A gene expression; tumor suppressor; colorectal cancer; TGFß signaling pathway
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000100032&lng=en&tlng=en

Abstract Colorectal cancer has become a serious problem, especially in highly developed countries. As reported by the World Health Organization, the number of colon cancer cases in the world in 2012 amounted to 1.36 million. It is the second most common cancer in females (614,000 cases, 9.2% of the total) and the third in males (746,000 cases, 10.0% of the total) worldwide. It is believed that TGFβ pathway elements are involved in the pathogenesis of colorectal cancer. This study assessed one of these elements, the ACVR2A gene. Qualitative and quantitative analyses of the ACVR2A gene in 84 patients with colorectal cancer was performed. There was no statistically significant association between ACVR2A gene expression and age, gender, histological type, grading of tumor, vascular invasion, and presence of lymphocytes in tumor tissue. No association was observed between the ACVR2A gene expression level and the presence of metastases in regional lymph nodes and distant metastases. In this study, larger tumors (T3 and T4) were characterized by higher ACVR2A expression compared to smaller tumors (T1 and T2). This may indicate an association between ACVR2A expression and the severity of pathological changes in the tumor growth process.