Structure–function insights reveal the human ribosome as a cancer target for antibiotics

Structure–function insights reveal the human ribosome as a cancer target for antibiotics

The ribosome of bacteria and other unicellular pathogens is a common target for antibiotic drugs. Here the authors determine a structure of the human ribosome bound to the translation inhibitor cycloheximide, and provide evidence that targeting the ribosome is a promising avenue for cancer therapy.

Bibliographic Details
Main Authors: Alexander G. Myasnikov, S. Kundhavai Natchiar, Marielle Nebout, Isabelle Hazemann, Véronique Imbert, Heena Khatter, Jean-François Peyron, Bruno P. Klaholz
Format: Article
Language:English
Published: Nature Publishing Group 2016-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12856
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spelling doaj-5c015c0b3ce04e609d082a4c3d51b4f22021-05-11T11:05:29ZengNature Publishing GroupNature Communications2041-17232016-09-01711810.1038/ncomms12856Structure–function insights reveal the human ribosome as a cancer target for antibioticsAlexander G. Myasnikov0S. Kundhavai Natchiar1Marielle Nebout2Isabelle Hazemann3Véronique Imbert4Heena Khatter5Jean-François Peyron6Bruno P. Klaholz7Department of Integrated Structural Biology, Centre for Integrative Biology (CBI), IGBMC (Institute of Genetics and of Molecular and Cellular Biology)Department of Integrated Structural Biology, Centre for Integrative Biology (CBI), IGBMC (Institute of Genetics and of Molecular and Cellular Biology)INSERM, U1065, Centre Méditerranéen de Médecine Moléculaire (C3M)Department of Integrated Structural Biology, Centre for Integrative Biology (CBI), IGBMC (Institute of Genetics and of Molecular and Cellular Biology)INSERM, U1065, Centre Méditerranéen de Médecine Moléculaire (C3M)Department of Integrated Structural Biology, Centre for Integrative Biology (CBI), IGBMC (Institute of Genetics and of Molecular and Cellular Biology)INSERM, U1065, Centre Méditerranéen de Médecine Moléculaire (C3M)Department of Integrated Structural Biology, Centre for Integrative Biology (CBI), IGBMC (Institute of Genetics and of Molecular and Cellular Biology)The ribosome of bacteria and other unicellular pathogens is a common target for antibiotic drugs. Here the authors determine a structure of the human ribosome bound to the translation inhibitor cycloheximide, and provide evidence that targeting the ribosome is a promising avenue for cancer therapy.https://doi.org/10.1038/ncomms12856
collection DOAJ
language English
format Article
sources DOAJ
author Alexander G. Myasnikov
S. Kundhavai Natchiar
Marielle Nebout
Isabelle Hazemann
Véronique Imbert
Heena Khatter
Jean-François Peyron
Bruno P. Klaholz
spellingShingle Alexander G. Myasnikov
S. Kundhavai Natchiar
Marielle Nebout
Isabelle Hazemann
Véronique Imbert
Heena Khatter
Jean-François Peyron
Bruno P. Klaholz
Structure–function insights reveal the human ribosome as a cancer target for antibiotics
Nature Communications
author_facet Alexander G. Myasnikov
S. Kundhavai Natchiar
Marielle Nebout
Isabelle Hazemann
Véronique Imbert
Heena Khatter
Jean-François Peyron
Bruno P. Klaholz
author_sort Alexander G. Myasnikov
title Structure–function insights reveal the human ribosome as a cancer target for antibiotics
title_short Structure–function insights reveal the human ribosome as a cancer target for antibiotics
title_full Structure–function insights reveal the human ribosome as a cancer target for antibiotics
title_fullStr Structure–function insights reveal the human ribosome as a cancer target for antibiotics
title_full_unstemmed Structure–function insights reveal the human ribosome as a cancer target for antibiotics
title_sort structure–function insights reveal the human ribosome as a cancer target for antibiotics
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-09-01
description The ribosome of bacteria and other unicellular pathogens is a common target for antibiotic drugs. Here the authors determine a structure of the human ribosome bound to the translation inhibitor cycloheximide, and provide evidence that targeting the ribosome is a promising avenue for cancer therapy.
url https://doi.org/10.1038/ncomms12856
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AT heenakhatter structurefunctioninsightsrevealthehumanribosomeasacancertargetforantibiotics
AT jeanfrancoispeyron structurefunctioninsightsrevealthehumanribosomeasacancertargetforantibiotics
AT brunopklaholz structurefunctioninsightsrevealthehumanribosomeasacancertargetforantibiotics
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