Azoxymethane Alters the Plasma Metabolome to a Greater Extent in Mice Fed a High-Fat Diet Compared to an AIN-93 Diet

Azoxymethane Alters the Plasma Metabolome to a Greater Extent in Mice Fed a High-Fat Diet Compared to an AIN-93 Diet

Consumption of a high-fat diet (HFD) links obesity to colon cancer in humans. Our data show that a HFD (45% energy fat versus 16% energy fat in an AIN-93 diet (AIN)) promotes azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) formation in a mouse cancer model. However, the underlying metab...

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Bibliographic Details
Main Authors:	Huawei Zeng, Shahid Umar, Zhenhua Liu, Michael R. Bukowski
Format:	Article
Language:	English
Published:	MDPI AG 2021-07-01
Series:	Metabolites
Subjects:	aberrant crypt foci azoxymethane colon cancer high-fat diet inflammation metabolome
Online Access:	https://www.mdpi.com/2218-1989/11/7/448

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