Clinical utility of transient elastography as an imaging tool to assess the short-term impact of laparoscopic sleeve gastrectomy, together with clinical and biochemical parameters and clinico-biochemical indices, on obese patients with nonalcoholic fatty liver disease: An Egyptian pilot study
Introduction: Nonalcoholic fatty liver disease (NAFLD) is a metabolic liver disorder commonly attributed to fatty acid deposition that can induce hepatic necroinflammation, defined as nonalcoholic steatohepatitis (NASH). It is strongly associated with obesity. Laparoscopic sleeve gastrectomy (LSG) i...
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2021-04-01
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English |
format |
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DOAJ |
author |
M.S. Abdelbary R. Marzaban H. Gamal Eldeen M. Khairy M. Menesy M.H. Fahmy A.M. Ayad B.S. Mouheb A. Yosry |
spellingShingle |
M.S. Abdelbary R. Marzaban H. Gamal Eldeen M. Khairy M. Menesy M.H. Fahmy A.M. Ayad B.S. Mouheb A. Yosry Clinical utility of transient elastography as an imaging tool to assess the short-term impact of laparoscopic sleeve gastrectomy, together with clinical and biochemical parameters and clinico-biochemical indices, on obese patients with nonalcoholic fatty liver disease: An Egyptian pilot study Revista de Gastroenterología de México (English Edition) Enfermedad de hígado graso no alcohólico Esteatohepatitis no alcohólica Gastrectomía laparoscópica en manga Cirugía bariátrica |
author_facet |
M.S. Abdelbary R. Marzaban H. Gamal Eldeen M. Khairy M. Menesy M.H. Fahmy A.M. Ayad B.S. Mouheb A. Yosry |
author_sort |
M.S. Abdelbary |
title |
Clinical utility of transient elastography as an imaging tool to assess the short-term impact of laparoscopic sleeve gastrectomy, together with clinical and biochemical parameters and clinico-biochemical indices, on obese patients with nonalcoholic fatty liver disease: An Egyptian pilot study |
title_short |
Clinical utility of transient elastography as an imaging tool to assess the short-term impact of laparoscopic sleeve gastrectomy, together with clinical and biochemical parameters and clinico-biochemical indices, on obese patients with nonalcoholic fatty liver disease: An Egyptian pilot study |
title_full |
Clinical utility of transient elastography as an imaging tool to assess the short-term impact of laparoscopic sleeve gastrectomy, together with clinical and biochemical parameters and clinico-biochemical indices, on obese patients with nonalcoholic fatty liver disease: An Egyptian pilot study |
title_fullStr |
Clinical utility of transient elastography as an imaging tool to assess the short-term impact of laparoscopic sleeve gastrectomy, together with clinical and biochemical parameters and clinico-biochemical indices, on obese patients with nonalcoholic fatty liver disease: An Egyptian pilot study |
title_full_unstemmed |
Clinical utility of transient elastography as an imaging tool to assess the short-term impact of laparoscopic sleeve gastrectomy, together with clinical and biochemical parameters and clinico-biochemical indices, on obese patients with nonalcoholic fatty liver disease: An Egyptian pilot study |
title_sort |
clinical utility of transient elastography as an imaging tool to assess the short-term impact of laparoscopic sleeve gastrectomy, together with clinical and biochemical parameters and clinico-biochemical indices, on obese patients with nonalcoholic fatty liver disease: an egyptian pilot study |
publisher |
Elsevier |
series |
Revista de Gastroenterología de México (English Edition) |
issn |
2255-534X |
publishDate |
2021-04-01 |
description |
Introduction: Nonalcoholic fatty liver disease (NAFLD) is a metabolic liver disorder commonly attributed to fatty acid deposition that can induce hepatic necroinflammation, defined as nonalcoholic steatohepatitis (NASH). It is strongly associated with obesity. Laparoscopic sleeve gastrectomy (LSG) is a favorable surgical modality for the treatment of morbid obesity. Aim: Our study evaluated the impact of LSG on patients with NAFLD and morbid obesity, 3 months after the operation, through clinical and biochemical characteristics, clinico-biochemical indices, and imaging parameters. Patients and methods: Morbidly obese patients with NAFLD ± NASH underwent LSG. They were thoroughly evaluated clinically (body weight, body mass index, waist circumference) and biochemically (transaminases and triglycerides), as well as through the fatty liver index (FLI), the hepatic steatosis index (HSI), and ultrasound elastography imaging studies (liver stiffness measurement [LSM] and the controlled attenuation parameter [CAP]), before and 3 months after the LSG. Results: Twenty-six obese patients with NAFLD underwent LSG that resulted in a significantly high reduction in all the parameters analyzed, except for liver transaminases. Conclusion: LSG is considered an efficient surgical modality for the treatment of morbidly obese patients with NAFLD. Resumen: Introducción: La enfermedad de hígado graso no alcohólico (EHGNA) es un trastorno metabólico del hígado atribuido al depósito de ácido graso que puede inducir necroinflamación hepática, definida como esteatohepatitis no alcohólica (EHNA). Está asociada de manera importante con la obesidad. La gastrectomía laparoscópica en manga (GLM) es una modalidad quirúrgica favorable para el tratamiento de la obesidad mórbida. Objetivo: Nuestro estudio evaluó el impacto de la GLM en pacientes con EHGNA y obesidad mórbida, 3 meses posterior a operación, por medio de características clínicas y bioquímicas, índices bioquímicos y parámetros de imagenología. Pacientes y métodos: Pacientes con obesidad mórbida con EHGNA con o sin EHNA se sometieron a una GLM. Fueron evaluados clínicamente (peso, IMC, circunferencia de cintura) y bioquímicamente (transaminasas y triglicéridos), al igual que con el índice de hígado graso (IHG), el índice de esteatosis hepática (IEH), y estudios de imagen de elastografía por ultrasonido (medición de rigidez hepática [MRH] y el parámetro de atenuación controlada [PAC]), previo a la GLM y 3 meses posoperatorio. Resultados: Veintiséis pacientes obesos con EHGNA se sometieron a una GLM que resultó en una reducción significativa de todos los parámetros analizados, excepto por las transaminasas hepáticas. Conclusión: La GLM es considerada una modalidad quirúrgica eficiente para el tratamiento de pacientes con obesidad mórbida y EHGNA. |
topic |
Enfermedad de hígado graso no alcohólico Esteatohepatitis no alcohólica Gastrectomía laparoscópica en manga Cirugía bariátrica |
url |
http://www.sciencedirect.com/science/article/pii/S2255534X21000396 |
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doaj-5c0f59ed1f704c679034904c6058b9462021-04-30T07:22:24ZengElsevierRevista de Gastroenterología de México (English Edition)2255-534X2021-04-01862125132Clinical utility of transient elastography as an imaging tool to assess the short-term impact of laparoscopic sleeve gastrectomy, together with clinical and biochemical parameters and clinico-biochemical indices, on obese patients with nonalcoholic fatty liver disease: An Egyptian pilot studyM.S. Abdelbary0R. Marzaban1H. Gamal Eldeen2M. Khairy3M. Menesy4M.H. Fahmy5A.M. Ayad6B.S. Mouheb7A. Yosry8Departamento de Medicina Tropical, Facultad de Medicina, Universidad de El Cairo, El Cairo, EgyptDepartamento de Medicina Tropical, Facultad de Medicina, Universidad de El Cairo, El Cairo, Egypt; Corresponding author. Domicilio: Kian 1 Tower (5/35), Zahraa AlMaadi (7th district), apartment 41, Cairo, Egypt.Departamento de Medicina Tropical, Facultad de Medicina, Universidad de El Cairo, El Cairo, EgyptDepartamento de Medicina Tropical, Facultad de Medicina, Universidad de El Cairo, El Cairo, EgyptDepartamento de Medicina Tropical, Facultad de Medicina, Universidad de El Cairo, El Cairo, EgyptDepartamento de Cirugía General, Facultad de Medicina, Universidad de El Cairo, El Cairo, EgyptDepartamento de Cirugía General, Facultad de Medicina, Universidad de El Cairo, El Cairo, EgyptDepartamento de Cirugía General, Facultad de Medicina, Universidad de El Cairo, El Cairo, EgyptDepartamento de Cirugía General, Facultad de Medicina, Universidad de El Cairo, El Cairo, EgyptIntroduction: Nonalcoholic fatty liver disease (NAFLD) is a metabolic liver disorder commonly attributed to fatty acid deposition that can induce hepatic necroinflammation, defined as nonalcoholic steatohepatitis (NASH). It is strongly associated with obesity. Laparoscopic sleeve gastrectomy (LSG) is a favorable surgical modality for the treatment of morbid obesity. Aim: Our study evaluated the impact of LSG on patients with NAFLD and morbid obesity, 3 months after the operation, through clinical and biochemical characteristics, clinico-biochemical indices, and imaging parameters. Patients and methods: Morbidly obese patients with NAFLD ± NASH underwent LSG. They were thoroughly evaluated clinically (body weight, body mass index, waist circumference) and biochemically (transaminases and triglycerides), as well as through the fatty liver index (FLI), the hepatic steatosis index (HSI), and ultrasound elastography imaging studies (liver stiffness measurement [LSM] and the controlled attenuation parameter [CAP]), before and 3 months after the LSG. Results: Twenty-six obese patients with NAFLD underwent LSG that resulted in a significantly high reduction in all the parameters analyzed, except for liver transaminases. Conclusion: LSG is considered an efficient surgical modality for the treatment of morbidly obese patients with NAFLD. Resumen: Introducción: La enfermedad de hígado graso no alcohólico (EHGNA) es un trastorno metabólico del hígado atribuido al depósito de ácido graso que puede inducir necroinflamación hepática, definida como esteatohepatitis no alcohólica (EHNA). Está asociada de manera importante con la obesidad. La gastrectomía laparoscópica en manga (GLM) es una modalidad quirúrgica favorable para el tratamiento de la obesidad mórbida. Objetivo: Nuestro estudio evaluó el impacto de la GLM en pacientes con EHGNA y obesidad mórbida, 3 meses posterior a operación, por medio de características clínicas y bioquímicas, índices bioquímicos y parámetros de imagenología. Pacientes y métodos: Pacientes con obesidad mórbida con EHGNA con o sin EHNA se sometieron a una GLM. Fueron evaluados clínicamente (peso, IMC, circunferencia de cintura) y bioquímicamente (transaminasas y triglicéridos), al igual que con el índice de hígado graso (IHG), el índice de esteatosis hepática (IEH), y estudios de imagen de elastografía por ultrasonido (medición de rigidez hepática [MRH] y el parámetro de atenuación controlada [PAC]), previo a la GLM y 3 meses posoperatorio. Resultados: Veintiséis pacientes obesos con EHGNA se sometieron a una GLM que resultó en una reducción significativa de todos los parámetros analizados, excepto por las transaminasas hepáticas. Conclusión: La GLM es considerada una modalidad quirúrgica eficiente para el tratamiento de pacientes con obesidad mórbida y EHGNA.http://www.sciencedirect.com/science/article/pii/S2255534X21000396Enfermedad de hígado graso no alcohólicoEsteatohepatitis no alcohólicaGastrectomía laparoscópica en mangaCirugía bariátrica |