Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity
Obesity is associated with low-grade chronic inflammation. Here the authors show that the activation of anti-inflammatory M2a-subtype macrophages requires the IL4/Irs2/Akt pathway. Due to decreased Irs2 expression this pathway is impaired in obese mice thus leading to a defect in M2a activation.
Bibliographic Details
Main Authors: |
Tetsuya Kubota,
Mariko Inoue,
Naoto Kubota,
Iseki Takamoto,
Tomoka Mineyama,
Kaito Iwayama,
Kumpei Tokuyama,
Masao Moroi,
Kohjiro Ueki,
Toshimasa Yamauchi,
Takashi Kadowaki |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2018-11-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-018-07358-9
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