Subthreshold laser treatment for reticular pseudodrusen secondary to age-related macular degeneration
Abstract There is a lack of treatment aimed at the regression of reticular pseudodrusen (RPD) secondary to age-related macular degeneration (AMD). The aim of this prospective, pilot study is to evaluate the safety and short-term efficacy of subthreshold laser treatment (SLT) in patients affected by...
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2021-01-01
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doaj-5c30f1b6e3f74e97aebf3b48a4ccd9592021-01-31T16:20:32ZengNature Publishing GroupScientific Reports2045-23222021-01-0111111010.1038/s41598-021-81810-7Subthreshold laser treatment for reticular pseudodrusen secondary to age-related macular degenerationGiuseppe Querques0Riccardo Sacconi1Francesco Gelormini2Enrico Borrelli3Francesco Prascina4Ilaria Zucchiatti5Lea Querques6Francesco Bandello7School of Medicine, Vita-Salute San Raffaele UniversitySchool of Medicine, Vita-Salute San Raffaele UniversitySchool of Medicine, Vita-Salute San Raffaele UniversitySchool of Medicine, Vita-Salute San Raffaele UniversityDivision of Head and Neck, Ophthalmology Unit, IRCCS San Raffaele Scientific InstituteDivision of Head and Neck, Ophthalmology Unit, IRCCS San Raffaele Scientific InstituteDivision of Head and Neck, Ophthalmology Unit, IRCCS San Raffaele Scientific InstituteSchool of Medicine, Vita-Salute San Raffaele UniversityAbstract There is a lack of treatment aimed at the regression of reticular pseudodrusen (RPD) secondary to age-related macular degeneration (AMD). The aim of this prospective, pilot study is to evaluate the safety and short-term efficacy of subthreshold laser treatment (SLT) in patients affected by RPD secondary to dry AMD (dAMD). Twenty eyes of 20 patients (mean age 78.4 ± 6.8 years) with RPD secondary to dAMD were prospectively enrolled. All patients were treated in an extrafoveal area of 1.27 mm2 using end-point management yellow subthreshold laser and followed for 3 months. Best-corrected visual acuity was 0.140 ± 0.09 LogMAR at the baseline and no changes were observed during the follow-up (p = 0.232). No significant worsening was disclosed before and after the treatment analyzing the macular sensitivity of the treated area (p = 0.152). No topical and/or systemic side effects were disclosed during the 3-month follow-up. The distribution among the RPD stages changed after the treatment (p < 0.001). In detail, in the treated area, we observed a significant increase in the number of Stage 1 RPD during the follow-up (p = 0.002), associated with a significant decrease of Stage 3 RPD (p = 0.020). Outer nuclear layer (ONL) thickness analysis showed a significant increase after the treatment associated with RPD regression (p = 0.001). End-point management SLT appears a safe treatment for RPD secondary to dAMD, showing short-term safety outcomes. Our results suggest that SLT could be effective in inducing a RPD regression in terms of RPD stage and ONL thickening.https://doi.org/10.1038/s41598-021-81810-7 |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Giuseppe Querques Riccardo Sacconi Francesco Gelormini Enrico Borrelli Francesco Prascina Ilaria Zucchiatti Lea Querques Francesco Bandello |
spellingShingle |
Giuseppe Querques Riccardo Sacconi Francesco Gelormini Enrico Borrelli Francesco Prascina Ilaria Zucchiatti Lea Querques Francesco Bandello Subthreshold laser treatment for reticular pseudodrusen secondary to age-related macular degeneration Scientific Reports |
author_facet |
Giuseppe Querques Riccardo Sacconi Francesco Gelormini Enrico Borrelli Francesco Prascina Ilaria Zucchiatti Lea Querques Francesco Bandello |
author_sort |
Giuseppe Querques |
title |
Subthreshold laser treatment for reticular pseudodrusen secondary to age-related macular degeneration |
title_short |
Subthreshold laser treatment for reticular pseudodrusen secondary to age-related macular degeneration |
title_full |
Subthreshold laser treatment for reticular pseudodrusen secondary to age-related macular degeneration |
title_fullStr |
Subthreshold laser treatment for reticular pseudodrusen secondary to age-related macular degeneration |
title_full_unstemmed |
Subthreshold laser treatment for reticular pseudodrusen secondary to age-related macular degeneration |
title_sort |
subthreshold laser treatment for reticular pseudodrusen secondary to age-related macular degeneration |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-01-01 |
description |
Abstract There is a lack of treatment aimed at the regression of reticular pseudodrusen (RPD) secondary to age-related macular degeneration (AMD). The aim of this prospective, pilot study is to evaluate the safety and short-term efficacy of subthreshold laser treatment (SLT) in patients affected by RPD secondary to dry AMD (dAMD). Twenty eyes of 20 patients (mean age 78.4 ± 6.8 years) with RPD secondary to dAMD were prospectively enrolled. All patients were treated in an extrafoveal area of 1.27 mm2 using end-point management yellow subthreshold laser and followed for 3 months. Best-corrected visual acuity was 0.140 ± 0.09 LogMAR at the baseline and no changes were observed during the follow-up (p = 0.232). No significant worsening was disclosed before and after the treatment analyzing the macular sensitivity of the treated area (p = 0.152). No topical and/or systemic side effects were disclosed during the 3-month follow-up. The distribution among the RPD stages changed after the treatment (p < 0.001). In detail, in the treated area, we observed a significant increase in the number of Stage 1 RPD during the follow-up (p = 0.002), associated with a significant decrease of Stage 3 RPD (p = 0.020). Outer nuclear layer (ONL) thickness analysis showed a significant increase after the treatment associated with RPD regression (p = 0.001). End-point management SLT appears a safe treatment for RPD secondary to dAMD, showing short-term safety outcomes. Our results suggest that SLT could be effective in inducing a RPD regression in terms of RPD stage and ONL thickening. |
url |
https://doi.org/10.1038/s41598-021-81810-7 |
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