Antibacterial Activity of Chalcone and Dihydrochalcone Compounds from Uvaria chamae Roots against Multidrug-Resistant Bacteria
This study presents antimicrobial properties of Uvaria chamae roots, commonly used for the treatment of various infections in south Benin. Their constituents were extracted and then fractionated in order to isolate the active ingredients. Antimicrobial susceptibility tests were performed against sev...
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doaj-5c529d011a884057a119f7609e66af1e2020-11-25T01:37:06ZengHindawi LimitedBioMed Research International2314-61332314-61412018-01-01201810.1155/2018/14531731453173Antibacterial Activity of Chalcone and Dihydrochalcone Compounds from Uvaria chamae Roots against Multidrug-Resistant BacteriaH. Koudokpon0N. Armstrong1T. V. Dougnon2L. Fah3E. Hounsa4H. S. Bankolé5F. Loko6E. Chabrière7J. M. Rolain8Research Unit in Applied Microbiology and Pharmacology of natural substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, 01 P.O. Box 2009, Cotonou, BeninAix Marseille Université, IRD, APHM, MEPHI, IHU Méditerranée Infection, 19-21, Boulevard Jean Moulin, 13385 Marseille Cedex 5, FranceResearch Unit in Applied Microbiology and Pharmacology of natural substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, 01 P.O. Box 2009, Cotonou, BeninResearch Unit in Applied Microbiology and Pharmacology of natural substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, 01 P.O. Box 2009, Cotonou, BeninResearch Unit in Applied Microbiology and Pharmacology of natural substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, 01 P.O. Box 2009, Cotonou, BeninResearch Unit in Applied Microbiology and Pharmacology of natural substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, 01 P.O. Box 2009, Cotonou, BeninResearch Unit in Applied Microbiology and Pharmacology of natural substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, 01 P.O. Box 2009, Cotonou, BeninAix Marseille Université, IRD, APHM, MEPHI, IHU Méditerranée Infection, 19-21, Boulevard Jean Moulin, 13385 Marseille Cedex 5, FranceAix Marseille Université, IRD, APHM, MEPHI, IHU Méditerranée Infection, 19-21, Boulevard Jean Moulin, 13385 Marseille Cedex 5, FranceThis study presents antimicrobial properties of Uvaria chamae roots, commonly used for the treatment of various infections in south Benin. Their constituents were extracted and then fractionated in order to isolate the active ingredients. Antimicrobial susceptibility tests were performed against several multidrug-resistant bacteria using the Mueller Hilton well agar diffusion method. Results showed that ethanol extracts were highly active against Gram-positive cocci. This activity was more extensive than that measured from conventional broad-spectrum antibiotics. Indeed, vancomycin-resistant enterococcus (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) strains were all sensitive to this root extract. The aim of this study was to link the antimicrobial activity of the root to chemical structures. The ion mobility mass spectrometry analysis revealed for the first time the presence of ten chalcone and dihydrochalcone structures responsible for the antimicrobial activity of Uvaria chamae ethanol extracts. Two structures were described here for the first time in these roots. These findings confirm and justify the medical properties of these roots used as a traditional medicine.http://dx.doi.org/10.1155/2018/1453173 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
H. Koudokpon N. Armstrong T. V. Dougnon L. Fah E. Hounsa H. S. Bankolé F. Loko E. Chabrière J. M. Rolain |
spellingShingle |
H. Koudokpon N. Armstrong T. V. Dougnon L. Fah E. Hounsa H. S. Bankolé F. Loko E. Chabrière J. M. Rolain Antibacterial Activity of Chalcone and Dihydrochalcone Compounds from Uvaria chamae Roots against Multidrug-Resistant Bacteria BioMed Research International |
author_facet |
H. Koudokpon N. Armstrong T. V. Dougnon L. Fah E. Hounsa H. S. Bankolé F. Loko E. Chabrière J. M. Rolain |
author_sort |
H. Koudokpon |
title |
Antibacterial Activity of Chalcone and Dihydrochalcone Compounds from Uvaria chamae Roots against Multidrug-Resistant Bacteria |
title_short |
Antibacterial Activity of Chalcone and Dihydrochalcone Compounds from Uvaria chamae Roots against Multidrug-Resistant Bacteria |
title_full |
Antibacterial Activity of Chalcone and Dihydrochalcone Compounds from Uvaria chamae Roots against Multidrug-Resistant Bacteria |
title_fullStr |
Antibacterial Activity of Chalcone and Dihydrochalcone Compounds from Uvaria chamae Roots against Multidrug-Resistant Bacteria |
title_full_unstemmed |
Antibacterial Activity of Chalcone and Dihydrochalcone Compounds from Uvaria chamae Roots against Multidrug-Resistant Bacteria |
title_sort |
antibacterial activity of chalcone and dihydrochalcone compounds from uvaria chamae roots against multidrug-resistant bacteria |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2018-01-01 |
description |
This study presents antimicrobial properties of Uvaria chamae roots, commonly used for the treatment of various infections in south Benin. Their constituents were extracted and then fractionated in order to isolate the active ingredients. Antimicrobial susceptibility tests were performed against several multidrug-resistant bacteria using the Mueller Hilton well agar diffusion method. Results showed that ethanol extracts were highly active against Gram-positive cocci. This activity was more extensive than that measured from conventional broad-spectrum antibiotics. Indeed, vancomycin-resistant enterococcus (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) strains were all sensitive to this root extract. The aim of this study was to link the antimicrobial activity of the root to chemical structures. The ion mobility mass spectrometry analysis revealed for the first time the presence of ten chalcone and dihydrochalcone structures responsible for the antimicrobial activity of Uvaria chamae ethanol extracts. Two structures were described here for the first time in these roots. These findings confirm and justify the medical properties of these roots used as a traditional medicine. |
url |
http://dx.doi.org/10.1155/2018/1453173 |
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