Seroepidemiology of human enterovirus71 and coxsackievirusA16 in Jiangsu province, China
<p>Abstract</p> <p>Background</p> <p>The major etiology of hand, foot and mouth disease (HFMD) is infection with human enterovirus A (HEV-A). Among subtypes of HEV-A, coxsackievirusA16 (CoxA16) and enterovirus 71 (EV71) are major causes for recurrent HFMD among infants...
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doaj-5c57049ea1d2447481846c99236ce46d2020-11-25T01:05:29ZengBMCVirology Journal1743-422X2012-10-019124810.1186/1743-422X-9-248Seroepidemiology of human enterovirus71 and coxsackievirusA16 in Jiangsu province, ChinaJi HongLi LiangLiu YanMingGe HengMingWang XuShanHu JianLiWu BinFu JianGuangZhang ZhenYuChen XiaoQinZhang MingLeiDing QiangXu WenBoTang FenYangZhou MingHaoWang HuaZhu FengCai<p>Abstract</p> <p>Background</p> <p>The major etiology of hand, foot and mouth disease (HFMD) is infection with human enterovirus A (HEV-A). Among subtypes of HEV-A, coxsackievirusA16 (CoxA16) and enterovirus 71 (EV71) are major causes for recurrent HFMD among infants and children in Jiangsu Province, mainland China. Here, we analyzed maternal antibodies between prenatal women and their neonates, to determine age-specific seroprevalence of human EV71 and CoxA16 infections in infants and children aged 0 to 15 years. The results may facilitate the development of immunization against HFMD.</p> <p>Methods</p> <p>This study used cross-section of 40 pairs of pregnant women and neonates and 800 subjects aged 1 month to 15 years old. Micro-dose cytopathogenic effects measured neutralizing antibodies against EV71 and CoxA16. Chi-square test compared seroprevalence rates between age groups and McNemar test, paired-Samples t-test and independent-samples t-test analyzed differences of geometric mean titers.</p> <p>Results</p> <p>A strong correlation between titers of neutralizing antibody against EV71 and CoxA16 in prenatal women and neonates was observed (r<sub>EV71</sub> = 0.67, r<sub>CoxA16</sub> = 0.56, respectively, <it>p</it> < 0.05). Seroprevalence rates of anti-EV71 antibody gradually decreased with age between 0 to 6 months old, remained low between 7 to 11 months (5.0–10.0%), and increased between 1 and 4 years (22.5–87.5%). Age-specific seroprevalence rates of anti-EV71 antibody stabilized in >80% of children between 5 to 15 years of age. However, seroprevalence rates of anti-CoxA16 antibody were very low (0.0–13.0%) between 0 to 6 months of age, gradually increased between 7 months to 4 years (15.0–70.0%), and stabilized at 54.0% (108/200) between 5 to 15 years. Seroprevalence rates against EV71 and CoxA16 were low under 1 year (0.0–10.0%), and showed an age dependent increase with high seroprevalence (52.5–62.5%) between 4 and10 years of age.</p> <p>Conclusions</p> <p>Concomitant infection of EV71 and CoxA16 was common in Jiangsu Province. Therefore, development of bivalent vaccine against both EV71 and CoxA16 is critical. The optimal schedule for vaccination may be 4 to11 months of age.</p> http://www.virologyj.com/content/9/1/248Human enterovirus71CoxsackievirusA16Maternally-acquired immunityNeutralizing antibodyHand, foot and mouth diseaseSeroepidemiology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ji Hong Li Liang Liu YanMing Ge HengMing Wang XuShan Hu JianLi Wu Bin Fu JianGuang Zhang ZhenYu Chen XiaoQin Zhang MingLei Ding Qiang Xu WenBo Tang FenYang Zhou MingHao Wang Hua Zhu FengCai |
spellingShingle |
Ji Hong Li Liang Liu YanMing Ge HengMing Wang XuShan Hu JianLi Wu Bin Fu JianGuang Zhang ZhenYu Chen XiaoQin Zhang MingLei Ding Qiang Xu WenBo Tang FenYang Zhou MingHao Wang Hua Zhu FengCai Seroepidemiology of human enterovirus71 and coxsackievirusA16 in Jiangsu province, China Virology Journal Human enterovirus71 CoxsackievirusA16 Maternally-acquired immunity Neutralizing antibody Hand, foot and mouth disease Seroepidemiology |
author_facet |
Ji Hong Li Liang Liu YanMing Ge HengMing Wang XuShan Hu JianLi Wu Bin Fu JianGuang Zhang ZhenYu Chen XiaoQin Zhang MingLei Ding Qiang Xu WenBo Tang FenYang Zhou MingHao Wang Hua Zhu FengCai |
author_sort |
Ji Hong |
title |
Seroepidemiology of human enterovirus71 and coxsackievirusA16 in Jiangsu province, China |
title_short |
Seroepidemiology of human enterovirus71 and coxsackievirusA16 in Jiangsu province, China |
title_full |
Seroepidemiology of human enterovirus71 and coxsackievirusA16 in Jiangsu province, China |
title_fullStr |
Seroepidemiology of human enterovirus71 and coxsackievirusA16 in Jiangsu province, China |
title_full_unstemmed |
Seroepidemiology of human enterovirus71 and coxsackievirusA16 in Jiangsu province, China |
title_sort |
seroepidemiology of human enterovirus71 and coxsackievirusa16 in jiangsu province, china |
publisher |
BMC |
series |
Virology Journal |
issn |
1743-422X |
publishDate |
2012-10-01 |
description |
<p>Abstract</p> <p>Background</p> <p>The major etiology of hand, foot and mouth disease (HFMD) is infection with human enterovirus A (HEV-A). Among subtypes of HEV-A, coxsackievirusA16 (CoxA16) and enterovirus 71 (EV71) are major causes for recurrent HFMD among infants and children in Jiangsu Province, mainland China. Here, we analyzed maternal antibodies between prenatal women and their neonates, to determine age-specific seroprevalence of human EV71 and CoxA16 infections in infants and children aged 0 to 15 years. The results may facilitate the development of immunization against HFMD.</p> <p>Methods</p> <p>This study used cross-section of 40 pairs of pregnant women and neonates and 800 subjects aged 1 month to 15 years old. Micro-dose cytopathogenic effects measured neutralizing antibodies against EV71 and CoxA16. Chi-square test compared seroprevalence rates between age groups and McNemar test, paired-Samples t-test and independent-samples t-test analyzed differences of geometric mean titers.</p> <p>Results</p> <p>A strong correlation between titers of neutralizing antibody against EV71 and CoxA16 in prenatal women and neonates was observed (r<sub>EV71</sub> = 0.67, r<sub>CoxA16</sub> = 0.56, respectively, <it>p</it> < 0.05). Seroprevalence rates of anti-EV71 antibody gradually decreased with age between 0 to 6 months old, remained low between 7 to 11 months (5.0–10.0%), and increased between 1 and 4 years (22.5–87.5%). Age-specific seroprevalence rates of anti-EV71 antibody stabilized in >80% of children between 5 to 15 years of age. However, seroprevalence rates of anti-CoxA16 antibody were very low (0.0–13.0%) between 0 to 6 months of age, gradually increased between 7 months to 4 years (15.0–70.0%), and stabilized at 54.0% (108/200) between 5 to 15 years. Seroprevalence rates against EV71 and CoxA16 were low under 1 year (0.0–10.0%), and showed an age dependent increase with high seroprevalence (52.5–62.5%) between 4 and10 years of age.</p> <p>Conclusions</p> <p>Concomitant infection of EV71 and CoxA16 was common in Jiangsu Province. Therefore, development of bivalent vaccine against both EV71 and CoxA16 is critical. The optimal schedule for vaccination may be 4 to11 months of age.</p> |
topic |
Human enterovirus71 CoxsackievirusA16 Maternally-acquired immunity Neutralizing antibody Hand, foot and mouth disease Seroepidemiology |
url |
http://www.virologyj.com/content/9/1/248 |
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