The G Protein-Coupled Receptor Kinases (GRKs) in Chemokine Receptor-Mediated Immune Cell Migration: From Molecular Cues to Physiopathology
Although G protein-coupled receptor kinases (GRKs) have long been known to regulate G protein-coupled receptor (GPCR) desensitization, their more recently characterized functions as scaffolds and signalling adapters underscore that this small family of proteins governs a larger array of physiologica...
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doaj-5c5a4905ae9a4538882747e9166129982021-01-06T00:03:03ZengMDPI AGCells2073-44092021-01-0110757510.3390/cells10010075The G Protein-Coupled Receptor Kinases (GRKs) in Chemokine Receptor-Mediated Immune Cell Migration: From Molecular Cues to PhysiopathologyMarta Laganà0Géraldine Schlecht-Louf1Françoise Bachelerie2Université Paris-Saclay: Inserm, Inflammation, Microbiome and Immunosurveillance, 92140 Clamart, FranceUniversité Paris-Saclay: Inserm, Inflammation, Microbiome and Immunosurveillance, 92140 Clamart, FranceUniversité Paris-Saclay: Inserm, Inflammation, Microbiome and Immunosurveillance, 92140 Clamart, FranceAlthough G protein-coupled receptor kinases (GRKs) have long been known to regulate G protein-coupled receptor (GPCR) desensitization, their more recently characterized functions as scaffolds and signalling adapters underscore that this small family of proteins governs a larger array of physiological functions than originally suspected. This review explores how GRKs contribute to the complex signalling networks involved in the migration of immune cells along chemokine gradients sensed by cell surface GPCRs. We outline emerging evidence indicating that the coordinated docking of several GRKs on an active chemokine receptor determines a specific receptor phosphorylation barcode that will translate into distinct signalling and migration outcomes. The guidance cues for neutrophil migration are emphasized based on several alterations affecting GRKs or GPCRs reported to be involved in pathological conditions.https://www.mdpi.com/2073-4409/10/1/75G protein-coupled receptor kinases (GRKs)chemokinesG protein-coupled receptors (GPCRs)atypical chemokine receptors (ACKRs)immune cell migrationchemoattractant gradients |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marta Laganà Géraldine Schlecht-Louf Françoise Bachelerie |
spellingShingle |
Marta Laganà Géraldine Schlecht-Louf Françoise Bachelerie The G Protein-Coupled Receptor Kinases (GRKs) in Chemokine Receptor-Mediated Immune Cell Migration: From Molecular Cues to Physiopathology Cells G protein-coupled receptor kinases (GRKs) chemokines G protein-coupled receptors (GPCRs) atypical chemokine receptors (ACKRs) immune cell migration chemoattractant gradients |
author_facet |
Marta Laganà Géraldine Schlecht-Louf Françoise Bachelerie |
author_sort |
Marta Laganà |
title |
The G Protein-Coupled Receptor Kinases (GRKs) in Chemokine Receptor-Mediated Immune Cell Migration: From Molecular Cues to Physiopathology |
title_short |
The G Protein-Coupled Receptor Kinases (GRKs) in Chemokine Receptor-Mediated Immune Cell Migration: From Molecular Cues to Physiopathology |
title_full |
The G Protein-Coupled Receptor Kinases (GRKs) in Chemokine Receptor-Mediated Immune Cell Migration: From Molecular Cues to Physiopathology |
title_fullStr |
The G Protein-Coupled Receptor Kinases (GRKs) in Chemokine Receptor-Mediated Immune Cell Migration: From Molecular Cues to Physiopathology |
title_full_unstemmed |
The G Protein-Coupled Receptor Kinases (GRKs) in Chemokine Receptor-Mediated Immune Cell Migration: From Molecular Cues to Physiopathology |
title_sort |
g protein-coupled receptor kinases (grks) in chemokine receptor-mediated immune cell migration: from molecular cues to physiopathology |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2021-01-01 |
description |
Although G protein-coupled receptor kinases (GRKs) have long been known to regulate G protein-coupled receptor (GPCR) desensitization, their more recently characterized functions as scaffolds and signalling adapters underscore that this small family of proteins governs a larger array of physiological functions than originally suspected. This review explores how GRKs contribute to the complex signalling networks involved in the migration of immune cells along chemokine gradients sensed by cell surface GPCRs. We outline emerging evidence indicating that the coordinated docking of several GRKs on an active chemokine receptor determines a specific receptor phosphorylation barcode that will translate into distinct signalling and migration outcomes. The guidance cues for neutrophil migration are emphasized based on several alterations affecting GRKs or GPCRs reported to be involved in pathological conditions. |
topic |
G protein-coupled receptor kinases (GRKs) chemokines G protein-coupled receptors (GPCRs) atypical chemokine receptors (ACKRs) immune cell migration chemoattractant gradients |
url |
https://www.mdpi.com/2073-4409/10/1/75 |
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