Monosodium glutamate induced testicular lesions in rats (histological study)
Objective: Monosodium glutamate (MSG) commonly consumed as a flavor enhancer and food additive in most soup, salad, and processed meat. The present study was designed to investigate the effect of MSG on testes of young male Wistar rats (n = 30). Materials and methods: They were randomly assigned int...
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Online Access: | http://www.sciencedirect.com/science/article/pii/S1110569013001143 |
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doaj-5c5e788ca05a4652a89beb662d0d10a82020-11-25T01:21:18ZengSpringerOpenMiddle East Fertility Society Journal1110-56902014-12-0119427428010.1016/j.mefs.2013.09.003Monosodium glutamate induced testicular lesions in rats (histological study)Aisha D. AlalwaniObjective: Monosodium glutamate (MSG) commonly consumed as a flavor enhancer and food additive in most soup, salad, and processed meat. The present study was designed to investigate the effect of MSG on testes of young male Wistar rats (n = 30). Materials and methods: They were randomly assigned into One control group C (n = 10) received distilled water and two treatment groups A and B (n = 10) were given oral daily doses of MSG 30 and 60 g/kg body weight respectively for 2 months. Results: The body weight of rats was significantly increased and mainly histological alterations which included of hyaline material in the lumina of the seminiferous tubules and interstitial tissues and exfoliation of spermatocytes and spermatids in treated group. Many cells of the different types of spermatogenesis appeared necrotic with pyknotic nuclei. Dilated congested blood vessels and vacuolar degeneration were also been observed in the cells of seminiferous tubules in the treated group B. Conclusions: MSG may have some deleterious effects on the testes of Wistar rats and by extension may contribute to the causes of male infertility. Thus, it is important to reconsider the usage of MSG as a flavor enhancer.http://www.sciencedirect.com/science/article/pii/S1110569013001143Monosodium glutamateMale ratsTestisHistopathology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aisha D. Alalwani |
spellingShingle |
Aisha D. Alalwani Monosodium glutamate induced testicular lesions in rats (histological study) Middle East Fertility Society Journal Monosodium glutamate Male rats Testis Histopathology |
author_facet |
Aisha D. Alalwani |
author_sort |
Aisha D. Alalwani |
title |
Monosodium glutamate induced testicular lesions in rats (histological study) |
title_short |
Monosodium glutamate induced testicular lesions in rats (histological study) |
title_full |
Monosodium glutamate induced testicular lesions in rats (histological study) |
title_fullStr |
Monosodium glutamate induced testicular lesions in rats (histological study) |
title_full_unstemmed |
Monosodium glutamate induced testicular lesions in rats (histological study) |
title_sort |
monosodium glutamate induced testicular lesions in rats (histological study) |
publisher |
SpringerOpen |
series |
Middle East Fertility Society Journal |
issn |
1110-5690 |
publishDate |
2014-12-01 |
description |
Objective: Monosodium glutamate (MSG) commonly consumed as a flavor enhancer and food additive in most soup, salad, and processed meat. The present study was designed to investigate the effect of MSG on testes of young male Wistar rats (n = 30).
Materials and methods: They were randomly assigned into One control group C (n = 10) received distilled water and two treatment groups A and B (n = 10) were given oral daily doses of MSG 30 and 60 g/kg body weight respectively for 2 months.
Results: The body weight of rats was significantly increased and mainly histological alterations which included of hyaline material in the lumina of the seminiferous tubules and interstitial tissues and exfoliation of spermatocytes and spermatids in treated group. Many cells of the different types of spermatogenesis appeared necrotic with pyknotic nuclei. Dilated congested blood vessels and vacuolar degeneration were also been observed in the cells of seminiferous tubules in the treated group B.
Conclusions: MSG may have some deleterious effects on the testes of Wistar rats and by extension may contribute to the causes of male infertility. Thus, it is important to reconsider the usage of MSG as a flavor enhancer. |
topic |
Monosodium glutamate Male rats Testis Histopathology |
url |
http://www.sciencedirect.com/science/article/pii/S1110569013001143 |
work_keys_str_mv |
AT aishadalalwani monosodiumglutamateinducedtesticularlesionsinratshistologicalstudy |
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