Association between mammographic breast density and histologic features of benign breast disease
Abstract Background Over 40% of women undergoing breast screening have mammographically dense breasts. Elevated mammographic breast density (MBD) is an established breast cancer risk factor and is known to mask tumors within the dense tissue. However, the association of MBD with high risk benign bre...
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doaj-5c5e827571f44adba68ff2aa0700b43d2021-04-02T11:05:40ZengBMCBreast Cancer Research1465-542X2017-12-0119111010.1186/s13058-017-0922-6Association between mammographic breast density and histologic features of benign breast diseaseKarthik Ghosh0Robert A. Vierkant1Ryan D. Frank2Stacey Winham3Daniel W. Visscher4Vernon S. Pankratz5Christopher G. Scott6Kathleen Brandt7Mark E. Sherman8Derek C. Radisky9Marlene H. Frost10Lynn C. Hartmann11Amy C. Degnim12Celine M. Vachon13General Internal Medicine, Breast Diagnostic Clinic, Mayo ClinicHealth Sciences Research, Mayo ClinicHealth Sciences Research, Mayo ClinicHealth Sciences Research, Mayo ClinicAnatomic Pathology, Mayo ClinicDepartment of Internal Medicine, University of New MexicoHealth Sciences Research, Mayo ClinicDepartment of Radiology, Mayo ClinicHealth Sciences Research, Mayo ClinicCancer Biology, Mayo ClinicWomen’s Cancer Program, Mayo ClinicWomen’s Cancer Program, Mayo ClinicWomen’s Cancer Program, Mayo ClinicHealth Sciences Research, Mayo ClinicAbstract Background Over 40% of women undergoing breast screening have mammographically dense breasts. Elevated mammographic breast density (MBD) is an established breast cancer risk factor and is known to mask tumors within the dense tissue. However, the association of MBD with high risk benign breast disease (BBD) is unknown. Method We analyzed data for 3400 women diagnosed with pathologically confirmed BBD in the Mayo Clinic BBD cohort from 1985–2001, with a clinical MBD measure (either parenchymal pattern (PP) or Breast Imaging Reporting and Data Systems (BI-RADS) density) and expert pathology review. Risk factor information was collected from medical records and questionnaires. MBD was dichotomized as dense (PP classification P2 or DY, or BI-RADS classification c or d) or non-dense (PP classification N1 or P1, or BI-RADS classification a or b). Associations of clinical and histologic characteristics with MBD were examined using logistic regression analysis to estimate odds ratios (ORs) with 95% confidence intervals (CIs). Results Of 3400 women in the study, 2163 (64%) had dense breasts. Adjusting for age and body mass index (BMI), there were positive associations of dense breasts with use of hormone therapy (HT), lack of lobular involution, presence of atypical lobular hyperplasia (ALH), histologic fibrosis, columnar cell hyperplasia/flat epithelia atypia (CCH/FEA), sclerosing adenosis (SA), cyst, usual ductal hyperplasia, and calcifications. In fully adjusted multivariate models, HT (1.3, 95% CI 1.1–1.5), ALH (1.5, 95% CI 1.0–2.2), lack of lobular involution (OR 1.6, 95% CI 1.2–2.1, compared to complete involution), fibrosis (OR 2.2, 95% CI 1.9–2.6) and CCH/FEA (OR 1.3, 95% CI 1.0–1.6) remained significantly associated with high MBD. Conclusion Our findings support an association between high risk BBD and high MBD, suggesting that risks associated with the latter may act early in breast carcinogenesis.http://link.springer.com/article/10.1186/s13058-017-0922-6 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Karthik Ghosh Robert A. Vierkant Ryan D. Frank Stacey Winham Daniel W. Visscher Vernon S. Pankratz Christopher G. Scott Kathleen Brandt Mark E. Sherman Derek C. Radisky Marlene H. Frost Lynn C. Hartmann Amy C. Degnim Celine M. Vachon |
spellingShingle |
Karthik Ghosh Robert A. Vierkant Ryan D. Frank Stacey Winham Daniel W. Visscher Vernon S. Pankratz Christopher G. Scott Kathleen Brandt Mark E. Sherman Derek C. Radisky Marlene H. Frost Lynn C. Hartmann Amy C. Degnim Celine M. Vachon Association between mammographic breast density and histologic features of benign breast disease Breast Cancer Research |
author_facet |
Karthik Ghosh Robert A. Vierkant Ryan D. Frank Stacey Winham Daniel W. Visscher Vernon S. Pankratz Christopher G. Scott Kathleen Brandt Mark E. Sherman Derek C. Radisky Marlene H. Frost Lynn C. Hartmann Amy C. Degnim Celine M. Vachon |
author_sort |
Karthik Ghosh |
title |
Association between mammographic breast density and histologic features of benign breast disease |
title_short |
Association between mammographic breast density and histologic features of benign breast disease |
title_full |
Association between mammographic breast density and histologic features of benign breast disease |
title_fullStr |
Association between mammographic breast density and histologic features of benign breast disease |
title_full_unstemmed |
Association between mammographic breast density and histologic features of benign breast disease |
title_sort |
association between mammographic breast density and histologic features of benign breast disease |
publisher |
BMC |
series |
Breast Cancer Research |
issn |
1465-542X |
publishDate |
2017-12-01 |
description |
Abstract Background Over 40% of women undergoing breast screening have mammographically dense breasts. Elevated mammographic breast density (MBD) is an established breast cancer risk factor and is known to mask tumors within the dense tissue. However, the association of MBD with high risk benign breast disease (BBD) is unknown. Method We analyzed data for 3400 women diagnosed with pathologically confirmed BBD in the Mayo Clinic BBD cohort from 1985–2001, with a clinical MBD measure (either parenchymal pattern (PP) or Breast Imaging Reporting and Data Systems (BI-RADS) density) and expert pathology review. Risk factor information was collected from medical records and questionnaires. MBD was dichotomized as dense (PP classification P2 or DY, or BI-RADS classification c or d) or non-dense (PP classification N1 or P1, or BI-RADS classification a or b). Associations of clinical and histologic characteristics with MBD were examined using logistic regression analysis to estimate odds ratios (ORs) with 95% confidence intervals (CIs). Results Of 3400 women in the study, 2163 (64%) had dense breasts. Adjusting for age and body mass index (BMI), there were positive associations of dense breasts with use of hormone therapy (HT), lack of lobular involution, presence of atypical lobular hyperplasia (ALH), histologic fibrosis, columnar cell hyperplasia/flat epithelia atypia (CCH/FEA), sclerosing adenosis (SA), cyst, usual ductal hyperplasia, and calcifications. In fully adjusted multivariate models, HT (1.3, 95% CI 1.1–1.5), ALH (1.5, 95% CI 1.0–2.2), lack of lobular involution (OR 1.6, 95% CI 1.2–2.1, compared to complete involution), fibrosis (OR 2.2, 95% CI 1.9–2.6) and CCH/FEA (OR 1.3, 95% CI 1.0–1.6) remained significantly associated with high MBD. Conclusion Our findings support an association between high risk BBD and high MBD, suggesting that risks associated with the latter may act early in breast carcinogenesis. |
url |
http://link.springer.com/article/10.1186/s13058-017-0922-6 |
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