Efficacy, accumulation, and transcriptional profile of anti-HIV shRNAs expressed from human U6, 7SK, and H1 promoters
The expression of short hairpin RNAs (shRNAs) in cells has many potential therapeutic applications, including as a functional cure for HIV. The RNA polymerase III promoters H1, 7SK, and U6 have all been used to express shRNAs. However, there have been no direct and simultaneous comparisons of shRNA...
Main Authors: | Ryan P. Goguen, Olivier Del Corpo, Camille M.G. Malard, Aïcha Daher, Sergio P. Alpuche-Lazcano, Michelle J. Chen, Robert J. Scarborough, Anne Gatignol |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-03-01
|
Series: | Molecular Therapy: Nucleic Acids |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2162253120304030 |
Similar Items
-
Optimized models for design of efficient miR30-based shRNAs
by: Olga V Matveeva, et al.
Published: (2012-08-01) -
Therapeutic Potency of Nanoformulations of siRNAs and shRNAs in Animal Models of Cancers
by: Md. Emranul Karim, et al.
Published: (2018-05-01) -
A streamlined method for the design and cloning of shRNAs into an optimized Dox-inducible lentiviral vector
by: Frank, Sander B., et al.
Published: (2017) -
Non-targeting control for MISSION shRNA library silences SNRPD3 leading to cell death or permanent growth arrest
by: Maria Czarnek, et al.
Published: (2021-12-01) -
Minimal-length Synthetic shRNAs Formulated with Lipid Nanoparticles are Potent Inhibitors of Hepatitis C Virus IRES-linked Gene Expression in Mice
by: Anne Dallas, et al.
Published: (2013-01-01)