Receptor repertoires of murine follicular T helper cells reveal a high clonal overlap in separate lymph nodes in autoimmunity

Receptor repertoires of murine follicular T helper cells reveal a high clonal overlap in separate lymph nodes in autoimmunity

Follicular T helper cells (Tfh) are a specialized subset of CD4 effector T cells that are crucial for germinal center (GC) reactions and for selecting B cells to undergo affinity maturation. Despite this central role for humoral immunity, only few data exist about their clonal distribution when mult...

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Bibliographic Details
Main Authors: Markus Niebuhr, Julia Belde, Anke Fähnrich, Arnauld Serge, Magali Irla, Christoph T Ellebrecht, Christoph M Hammers, Katja Bieber, Jürgen Westermann, Kathrin Kalies
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-08-01
Series:eLife
Subjects:
adaptive immunity
germinal center reactions
follicular T helper cells
T cell antigen
receptor sequences
clonal selection
Online Access:https://elifesciences.org/articles/70053

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