Synthesis, Characterization, and Antibacterial Activity of Cross-Linked Chitosan-Glutaraldehyde
This present study deals with synthesis, characterization and antibacterial activity of cross-linked chitosan-glutaraldehyde. Results from this study indicated that cross-linked chitosan-glutaraldehyde markedly inhibited the growth of antibiotic-resistant Burkholderia cepacia complex regardless of b...
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2013-05-01
|
Series: | Marine Drugs |
Subjects: | |
Online Access: | http://www.mdpi.com/1660-3397/11/5/1534 |
id |
doaj-5c6d4c3733b2443a8c24ba5b5ff876ea |
---|---|
record_format |
Article |
spelling |
doaj-5c6d4c3733b2443a8c24ba5b5ff876ea2020-11-24T21:12:12ZengMDPI AGMarine Drugs1660-33972013-05-011151534155210.3390/md11051534Synthesis, Characterization, and Antibacterial Activity of Cross-Linked Chitosan-GlutaraldehydeLong-Biao GuoGuan-Lin XieGuo-Chang SunMuhammad IbrahimLi-Rong HanFei XuYang-Li WangYuan FangChang-Lin ShanQing ZhouBin LiThis present study deals with synthesis, characterization and antibacterial activity of cross-linked chitosan-glutaraldehyde. Results from this study indicated that cross-linked chitosan-glutaraldehyde markedly inhibited the growth of antibiotic-resistant Burkholderia cepacia complex regardless of bacterial species and incubation time while bacterial growth was unaffected by solid chitosan. Furthermore, high temperature treated cross-linked chitosan-glutaraldehyde showed strong antibacterial activity against the selected strain 0901 although the inhibitory effects varied with different temperatures. In addition, physical-chemical and structural characterization revealed that the cross-linking of chitosan with glutaraldehyde resulted in a rougher surface morphology, a characteristic Fourier transform infrared (FTIR) band at 1559 cm−1, a specific X-ray diffraction peak centered at 2θ = 15°, a lower contents of carbon, hydrogen and nitrogen, and a higher stability of glucose units compared to chitosan based on scanning electron microscopic observation, FTIR spectra, X-ray diffraction pattern, as well as elemental and thermo gravimetric analysis. Overall, this study indicated that cross-linked chitosan-glutaraldehyde is promising to be developed as a new antibacterial drug.http://www.mdpi.com/1660-3397/11/5/1534antibacterial activitycharacterizationchitosancross-linkglutaraldehyde |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Long-Biao Guo Guan-Lin Xie Guo-Chang Sun Muhammad Ibrahim Li-Rong Han Fei Xu Yang-Li Wang Yuan Fang Chang-Lin Shan Qing Zhou Bin Li |
spellingShingle |
Long-Biao Guo Guan-Lin Xie Guo-Chang Sun Muhammad Ibrahim Li-Rong Han Fei Xu Yang-Li Wang Yuan Fang Chang-Lin Shan Qing Zhou Bin Li Synthesis, Characterization, and Antibacterial Activity of Cross-Linked Chitosan-Glutaraldehyde Marine Drugs antibacterial activity characterization chitosan cross-link glutaraldehyde |
author_facet |
Long-Biao Guo Guan-Lin Xie Guo-Chang Sun Muhammad Ibrahim Li-Rong Han Fei Xu Yang-Li Wang Yuan Fang Chang-Lin Shan Qing Zhou Bin Li |
author_sort |
Long-Biao Guo |
title |
Synthesis, Characterization, and Antibacterial Activity of Cross-Linked Chitosan-Glutaraldehyde |
title_short |
Synthesis, Characterization, and Antibacterial Activity of Cross-Linked Chitosan-Glutaraldehyde |
title_full |
Synthesis, Characterization, and Antibacterial Activity of Cross-Linked Chitosan-Glutaraldehyde |
title_fullStr |
Synthesis, Characterization, and Antibacterial Activity of Cross-Linked Chitosan-Glutaraldehyde |
title_full_unstemmed |
Synthesis, Characterization, and Antibacterial Activity of Cross-Linked Chitosan-Glutaraldehyde |
title_sort |
synthesis, characterization, and antibacterial activity of cross-linked chitosan-glutaraldehyde |
publisher |
MDPI AG |
series |
Marine Drugs |
issn |
1660-3397 |
publishDate |
2013-05-01 |
description |
This present study deals with synthesis, characterization and antibacterial activity of cross-linked chitosan-glutaraldehyde. Results from this study indicated that cross-linked chitosan-glutaraldehyde markedly inhibited the growth of antibiotic-resistant Burkholderia cepacia complex regardless of bacterial species and incubation time while bacterial growth was unaffected by solid chitosan. Furthermore, high temperature treated cross-linked chitosan-glutaraldehyde showed strong antibacterial activity against the selected strain 0901 although the inhibitory effects varied with different temperatures. In addition, physical-chemical and structural characterization revealed that the cross-linking of chitosan with glutaraldehyde resulted in a rougher surface morphology, a characteristic Fourier transform infrared (FTIR) band at 1559 cm−1, a specific X-ray diffraction peak centered at 2θ = 15°, a lower contents of carbon, hydrogen and nitrogen, and a higher stability of glucose units compared to chitosan based on scanning electron microscopic observation, FTIR spectra, X-ray diffraction pattern, as well as elemental and thermo gravimetric analysis. Overall, this study indicated that cross-linked chitosan-glutaraldehyde is promising to be developed as a new antibacterial drug. |
topic |
antibacterial activity characterization chitosan cross-link glutaraldehyde |
url |
http://www.mdpi.com/1660-3397/11/5/1534 |
work_keys_str_mv |
AT longbiaoguo synthesischaracterizationandantibacterialactivityofcrosslinkedchitosanglutaraldehyde AT guanlinxie synthesischaracterizationandantibacterialactivityofcrosslinkedchitosanglutaraldehyde AT guochangsun synthesischaracterizationandantibacterialactivityofcrosslinkedchitosanglutaraldehyde AT muhammadibrahim synthesischaracterizationandantibacterialactivityofcrosslinkedchitosanglutaraldehyde AT lironghan synthesischaracterizationandantibacterialactivityofcrosslinkedchitosanglutaraldehyde AT feixu synthesischaracterizationandantibacterialactivityofcrosslinkedchitosanglutaraldehyde AT yangliwang synthesischaracterizationandantibacterialactivityofcrosslinkedchitosanglutaraldehyde AT yuanfang synthesischaracterizationandantibacterialactivityofcrosslinkedchitosanglutaraldehyde AT changlinshan synthesischaracterizationandantibacterialactivityofcrosslinkedchitosanglutaraldehyde AT qingzhou synthesischaracterizationandantibacterialactivityofcrosslinkedchitosanglutaraldehyde AT binli synthesischaracterizationandantibacterialactivityofcrosslinkedchitosanglutaraldehyde |
_version_ |
1716751263781093376 |