Flavonoids from the Amazon plant Brosimum acutifolium induce C6 glioma cell line apoptosis by disrupting mitochondrial membrane potential and reducing AKT phosphorylation

Flavonoids from the Amazon plant Brosimum acutifolium induce C6 glioma cell line apoptosis by disrupting mitochondrial membrane potential and reducing AKT phosphorylation

Glioblastoma, which is highly invasive and has a poor patient prognosis, is the most common type of brain tumor. Flavonoids have known antiproliferative and antineoplastic effects, such as apoptosis induction and tumor growth inhibition. We investigated the effects of treatment with three flavonoids...

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Bibliographic Details
Main Authors: L.A.L. Maués, G.M. Alves, N.M.G. Couto, B.J.M. da Silva, M.S.P. Arruda, B.M. Macchi, C.B.C. Sena, A.F. Prado, M.E. Crespo-Lopez, E.O. Silva, J.L.M. do Nascimento
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
C6 glioma cell line
Brosimum acutifolium
Flavonoids
Antiproliferation
Apoptosis and AKT
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218385378

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