Genetic transmission networks of HIV-1 CRF07_BC strain among HIV-1 infections with virologic failure of ART in a minority area of China: a population-based study
Abstract Background The drug resistance and the virologic failure of antiretroviral therapy (ART) are quite severe in Liangshan. A better understanding of the virologic failure of ART and the HIV-1 transmission network dynamics is essential for the surveillance and prevention of HIV. Here, we analyz...
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doaj-5c73afaf72444711b97b0e48e1f1d7262020-11-25T03:35:02ZengBMCBMC Infectious Diseases1471-23342020-08-0120111110.1186/s12879-020-05347-2Genetic transmission networks of HIV-1 CRF07_BC strain among HIV-1 infections with virologic failure of ART in a minority area of China: a population-based studyDan Yuan0Meijing Liu1Yiping Li2Peng Jia3Ling Su4Li Ye5Yan Zhang6Pan Ling7Chang Zhou8Shu Liang9Hong Yang10Honglu Liu11Shujuan Yang12Center for AIDS/STD Control and Prevention, Sichuan Center for Disease Control and PreventionWest China School of Public Health and West China Fourth Hospital, Sichuan UniversityCenter for AIDS/STD Control and Prevention, Sichuan Center for Disease Control and PreventionInternational Institute of Spatial Lifecourse Epidemiology (ISLE)Center for AIDS/STD Control and Prevention, Sichuan Center for Disease Control and PreventionCenter for AIDS/STD Control and Prevention, Sichuan Center for Disease Control and PreventionCenter for AIDS/STD Control and Prevention, Sichuan Center for Disease Control and PreventionCenter for AIDS/STD Control and Prevention, Sichuan Center for Disease Control and PreventionCenter for AIDS/STD Control and Prevention, Sichuan Center for Disease Control and PreventionCenter for AIDS/STD Control and Prevention, Sichuan Center for Disease Control and PreventionCenter for AIDS/STD Control and Prevention, Sichuan Center for Disease Control and PreventionCenter for AIDS/STD Control and Prevention, Sichuan Center for Disease Control and PreventionInternational Institute of Spatial Lifecourse Epidemiology (ISLE)Abstract Background The drug resistance and the virologic failure of antiretroviral therapy (ART) are quite severe in Liangshan. A better understanding of the virologic failure of ART and the HIV-1 transmission network dynamics is essential for the surveillance and prevention of HIV. Here, we analyzed the HIV-1 CRF07_BC strain genetic transmission networks and their associated factors among people living with HIV-1 (PLWH) who had virologic failure of ART by using close genetic links. Methods The drug-resistant mutations were determined using the Stanford University HIV Drug Resistance Database. HIV-1 pol genes sequences were used for phylogenetic and genotypic drug resistance analysis. The genetic transmission networks were performed by comparing sequences, constructing the phylogenetic tree, calculating the pairwise distance, and visualizing the network. Results A total of 1050 PLWH with CRF07_BC pol sequences were finally identified and included in the genetic transmission network analysis from 2016 to 2017. Of the 1050 CRF07_BC pol sequences, 346 (32.95%) fell into clusters at a genetic distance of 0.006, resulting in 137 clusters ranging in size from 2 to 40 individuals. Subjects who were widowed or divorced were less likely to form a genetic transmission network (adjusted OR: 0.50), while subjects who had shared a needle ≥ five times were more likely to form a network (adjusted OR: 1.88). Conclusions The genetic transmission networks revealed the complex transmission pattern, highlighting the urgent need for transmission monitoring of virologic failure of ART and selection of more effective therapeutic regimens to promote viral suppression.http://link.springer.com/article/10.1186/s12879-020-05347-2HIV-1Genetic transmission networkCRF07_BCVirologic failureAntiretroviral therapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dan Yuan Meijing Liu Yiping Li Peng Jia Ling Su Li Ye Yan Zhang Pan Ling Chang Zhou Shu Liang Hong Yang Honglu Liu Shujuan Yang |
spellingShingle |
Dan Yuan Meijing Liu Yiping Li Peng Jia Ling Su Li Ye Yan Zhang Pan Ling Chang Zhou Shu Liang Hong Yang Honglu Liu Shujuan Yang Genetic transmission networks of HIV-1 CRF07_BC strain among HIV-1 infections with virologic failure of ART in a minority area of China: a population-based study BMC Infectious Diseases HIV-1 Genetic transmission network CRF07_BC Virologic failure Antiretroviral therapy |
author_facet |
Dan Yuan Meijing Liu Yiping Li Peng Jia Ling Su Li Ye Yan Zhang Pan Ling Chang Zhou Shu Liang Hong Yang Honglu Liu Shujuan Yang |
author_sort |
Dan Yuan |
title |
Genetic transmission networks of HIV-1 CRF07_BC strain among HIV-1 infections with virologic failure of ART in a minority area of China: a population-based study |
title_short |
Genetic transmission networks of HIV-1 CRF07_BC strain among HIV-1 infections with virologic failure of ART in a minority area of China: a population-based study |
title_full |
Genetic transmission networks of HIV-1 CRF07_BC strain among HIV-1 infections with virologic failure of ART in a minority area of China: a population-based study |
title_fullStr |
Genetic transmission networks of HIV-1 CRF07_BC strain among HIV-1 infections with virologic failure of ART in a minority area of China: a population-based study |
title_full_unstemmed |
Genetic transmission networks of HIV-1 CRF07_BC strain among HIV-1 infections with virologic failure of ART in a minority area of China: a population-based study |
title_sort |
genetic transmission networks of hiv-1 crf07_bc strain among hiv-1 infections with virologic failure of art in a minority area of china: a population-based study |
publisher |
BMC |
series |
BMC Infectious Diseases |
issn |
1471-2334 |
publishDate |
2020-08-01 |
description |
Abstract Background The drug resistance and the virologic failure of antiretroviral therapy (ART) are quite severe in Liangshan. A better understanding of the virologic failure of ART and the HIV-1 transmission network dynamics is essential for the surveillance and prevention of HIV. Here, we analyzed the HIV-1 CRF07_BC strain genetic transmission networks and their associated factors among people living with HIV-1 (PLWH) who had virologic failure of ART by using close genetic links. Methods The drug-resistant mutations were determined using the Stanford University HIV Drug Resistance Database. HIV-1 pol genes sequences were used for phylogenetic and genotypic drug resistance analysis. The genetic transmission networks were performed by comparing sequences, constructing the phylogenetic tree, calculating the pairwise distance, and visualizing the network. Results A total of 1050 PLWH with CRF07_BC pol sequences were finally identified and included in the genetic transmission network analysis from 2016 to 2017. Of the 1050 CRF07_BC pol sequences, 346 (32.95%) fell into clusters at a genetic distance of 0.006, resulting in 137 clusters ranging in size from 2 to 40 individuals. Subjects who were widowed or divorced were less likely to form a genetic transmission network (adjusted OR: 0.50), while subjects who had shared a needle ≥ five times were more likely to form a network (adjusted OR: 1.88). Conclusions The genetic transmission networks revealed the complex transmission pattern, highlighting the urgent need for transmission monitoring of virologic failure of ART and selection of more effective therapeutic regimens to promote viral suppression. |
topic |
HIV-1 Genetic transmission network CRF07_BC Virologic failure Antiretroviral therapy |
url |
http://link.springer.com/article/10.1186/s12879-020-05347-2 |
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