Nedd4-2 and the regulation of epithelial sodium transport
Nedd4-2 is a ubiquitin ligase previously demonstrated to regulate endocytosis and lysosomal degradation of the epithelial Na+ channel (ENaC) and other ion channels and transporters. Recent studies using Nedd4-2 knockout mice specifically in kidney or lung epithelia has revealed a critical role for t...
Main Authors: | Daniela eRotin, Olivier eStaub |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2012-06-01
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Series: | Frontiers in Physiology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00212/full |
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