Study on the Efficacy and Mechanism of <i>Lycium barbarum</i> Polysaccharide against Lead-Induced Renal Injury in Mice
Lead is one of the most common heavy metal pollutants in the environment. Prolonged exposure to lead will induce oxidative stress, inflammation, and apoptosis in the kidneys, which in turn causes kidney injury. <i>Lycium barbarum</i> polysaccharide (LBP) is well known for its numerous ph...
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doaj-5c7eb0cceb554ade8758831298787e092021-09-26T00:50:54ZengMDPI AGNutrients2072-66432021-08-01132945294510.3390/nu13092945Study on the Efficacy and Mechanism of <i>Lycium barbarum</i> Polysaccharide against Lead-Induced Renal Injury in MiceWen Xie0Yuan-Yuan Huang1Hua-Guo Chen2Xin Zhou3Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment, Guizhou Normal University, 116 Baoshan North Rd., Guiyang 550001, ChinaKey Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment, Guizhou Normal University, 116 Baoshan North Rd., Guiyang 550001, ChinaKey Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment, Guizhou Normal University, 116 Baoshan North Rd., Guiyang 550001, ChinaKey Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment, Guizhou Normal University, 116 Baoshan North Rd., Guiyang 550001, ChinaLead is one of the most common heavy metal pollutants in the environment. Prolonged exposure to lead will induce oxidative stress, inflammation, and apoptosis in the kidneys, which in turn causes kidney injury. <i>Lycium barbarum</i> polysaccharide (LBP) is well known for its numerous pharmacological properties. This study aims to explore the efficacy and mechanism of LBP against lead-induced kidney damage in mice. Symptoms of renal injury were induced in mice by using 25 mg/kg lead acetate (PbAc<sub>2</sub>), and different doses of LBP (200, 400, and 600 mg/kg BW) were orally administrated to PbAc<sub>2</sub>-treated mice for five weeks. The results of the pharmacodynamics experiment showed that the renal pathological damages, serum creatinine (Cre), blood urea nitrogen (BUN), and kidney index of PbAc<sub>2</sub>-treated mice could be significantly alleviated by treatment with LBP. Further, LBP treatment significantly increased the weight and feed intake of PbAc<sub>2</sub>-treated mice. The dose effect results indicated that a medium dose of LBP was superior to high and low doses. The results of mechanistic experiments showed that LBP could attenuate oxidative stress, inflammation, and apoptosis in the kidneys of mice with lead toxicity by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway.https://www.mdpi.com/2072-6643/13/9/2945<i>Lycium barbarum</i> polysaccharidelead-induced renal injuryoxidative stressinflammatoryapoptosisNrf2 signaling pathway |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wen Xie Yuan-Yuan Huang Hua-Guo Chen Xin Zhou |
spellingShingle |
Wen Xie Yuan-Yuan Huang Hua-Guo Chen Xin Zhou Study on the Efficacy and Mechanism of <i>Lycium barbarum</i> Polysaccharide against Lead-Induced Renal Injury in Mice Nutrients <i>Lycium barbarum</i> polysaccharide lead-induced renal injury oxidative stress inflammatory apoptosis Nrf2 signaling pathway |
author_facet |
Wen Xie Yuan-Yuan Huang Hua-Guo Chen Xin Zhou |
author_sort |
Wen Xie |
title |
Study on the Efficacy and Mechanism of <i>Lycium barbarum</i> Polysaccharide against Lead-Induced Renal Injury in Mice |
title_short |
Study on the Efficacy and Mechanism of <i>Lycium barbarum</i> Polysaccharide against Lead-Induced Renal Injury in Mice |
title_full |
Study on the Efficacy and Mechanism of <i>Lycium barbarum</i> Polysaccharide against Lead-Induced Renal Injury in Mice |
title_fullStr |
Study on the Efficacy and Mechanism of <i>Lycium barbarum</i> Polysaccharide against Lead-Induced Renal Injury in Mice |
title_full_unstemmed |
Study on the Efficacy and Mechanism of <i>Lycium barbarum</i> Polysaccharide against Lead-Induced Renal Injury in Mice |
title_sort |
study on the efficacy and mechanism of <i>lycium barbarum</i> polysaccharide against lead-induced renal injury in mice |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2021-08-01 |
description |
Lead is one of the most common heavy metal pollutants in the environment. Prolonged exposure to lead will induce oxidative stress, inflammation, and apoptosis in the kidneys, which in turn causes kidney injury. <i>Lycium barbarum</i> polysaccharide (LBP) is well known for its numerous pharmacological properties. This study aims to explore the efficacy and mechanism of LBP against lead-induced kidney damage in mice. Symptoms of renal injury were induced in mice by using 25 mg/kg lead acetate (PbAc<sub>2</sub>), and different doses of LBP (200, 400, and 600 mg/kg BW) were orally administrated to PbAc<sub>2</sub>-treated mice for five weeks. The results of the pharmacodynamics experiment showed that the renal pathological damages, serum creatinine (Cre), blood urea nitrogen (BUN), and kidney index of PbAc<sub>2</sub>-treated mice could be significantly alleviated by treatment with LBP. Further, LBP treatment significantly increased the weight and feed intake of PbAc<sub>2</sub>-treated mice. The dose effect results indicated that a medium dose of LBP was superior to high and low doses. The results of mechanistic experiments showed that LBP could attenuate oxidative stress, inflammation, and apoptosis in the kidneys of mice with lead toxicity by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway. |
topic |
<i>Lycium barbarum</i> polysaccharide lead-induced renal injury oxidative stress inflammatory apoptosis Nrf2 signaling pathway |
url |
https://www.mdpi.com/2072-6643/13/9/2945 |
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