Clinical Implications of DNA Repair Defects in High-Grade Serous Ovarian Carcinomas

Clinical Implications of DNA Repair Defects in High-Grade Serous Ovarian Carcinomas

Despite significant improvements in surgical and medical management, high grade serous ovarian cancer (HGSOC) still represents the deadliest gynecologic malignancy and the fifth most frequent cause of cancer-related mortality in women in the USA. Since DNA repair alterations are regarded as the “the...

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Bibliographic Details
Main Authors: Michela Camilla Milanesio, Silvia Giordano, Giorgio Valabrega
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cancers
Subjects:
epithelial ovarian cancer
DNA repair deficiency
DNA homologous recombination
DNA mismatch repair
PARP inhibitors
BRCA reversion mutations
Online Access:https://www.mdpi.com/2072-6694/12/5/1315

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