Humoral immunity to mumps in a highly vaccinated population in Taiwan
Background: A resurgence of mumps was noted recently and outbreaks were increasingly reported in populations with high vaccine coverage. We aimed to evaluate the seroprevalence to mumps in Taiwan, where a two-dose childhood mumps-containing vaccine program, with a high coverage rate, had been implem...
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doaj-5c893f71d9da4f22b7a9830bedd8e4bb2020-11-25T02:22:47ZengElsevierJournal of Microbiology, Immunology and Infection1684-11822019-06-01523379385Humoral immunity to mumps in a highly vaccinated population in TaiwanYu-Huai Ho0Chen-Chi Tsai1Ya-Wen Tsai2Yu-Chiang Wang3Tzou-Yien Lin4De-Jen Lee5Chih-Jung Chen6Section of Infectious Disease, Department of Medicine, Buddhist Tzu Chi General Hospital, Hualien, Taiwan; School of Medicine, Tzu Chi University, Hualien, TaiwanSchool of Medicine, Tzu Chi University, Hualien, Taiwan; Section of Infectious Disease, Department of Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, TaiwanSchool of Medicine, College of Medicine, Chang Gung University, 333, Taoyuan, TaiwanSchool of Medicine, College of Medicine, Chang Gung University, 333, Taoyuan, TaiwanSchool of Medicine, College of Medicine, Chang Gung University, 333, Taoyuan, Taiwan; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children's Hospital and Chang Gung Memorial Hospital, 333, Taoyuan, TaiwanPhysical Education Office, Chang Gung University, 333, Taoyuan, Taiwan; Corresponding author. Physical Education Office, Chang Gung University, No. 259, Wunhua 1st Rd., Kweishan 333, Taoyuan, Taiwan.School of Medicine, College of Medicine, Chang Gung University, 333, Taoyuan, Taiwan; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children's Hospital and Chang Gung Memorial Hospital, 333, Taoyuan, Taiwan; Corresponding author. Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Linkou, No. 5, Fu-Shin Street, Kweishan 333, Taoyuan, Taiwan. Fax: +886 3 3971827.Background: A resurgence of mumps was noted recently and outbreaks were increasingly reported in populations with high vaccine coverage. We aimed to evaluate the seroprevalence to mumps in Taiwan, where a two-dose childhood mumps-containing vaccine program, with a high coverage rate, had been implemented for >20 years. Methods: The anti-mumps IgG was determined in 3552 participants of all ages in Taiwan. The age-specific seropositivity rates were calculated and the sociodemographic variables associated with the seronegative sera were analyzed with a logistic regression method. Results: The overall seroprevalence to mumps was 71%, with a higher rate in adults ≥19 years old than in the pediatric population <19 years old (80.4% versus 62.0%, P < 0.0001). In participants aged 2–20 years, who had been given at least one mumps-containing vaccine, the seropositivity fluctuated across different age subgroups and the lowest rate (36.8%) occurred in the 17–18 years age group. The multivariate analysis identified age within 17–18 years (adjusted odds ratio [aOR] 8.598, 95% confidence interval [CI] 2.990–24.722, P < 0.0001), within 19–20 years (aOR 5.076, 95% CI 1.702–15.133, P = 0.0080), and being a resident of the suburban area of northern Taiwan (aOR 1.089, 95% CI 0.823–1.414, P = 0.0008) as independent factors associated with an increased risk of seronegative sera. Conclusion: The seropositivity to mumps was unexpectedly low in highly vaccinated generations, and with a significant geographical discrepancy in Taiwan, which may have been responsible for the sustained reports of mumps cases in Taiwan. Keywords: Mumps, Seroprevalence, Humoral immunity, Taiwanhttp://www.sciencedirect.com/science/article/pii/S168411821730227X |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yu-Huai Ho Chen-Chi Tsai Ya-Wen Tsai Yu-Chiang Wang Tzou-Yien Lin De-Jen Lee Chih-Jung Chen |
spellingShingle |
Yu-Huai Ho Chen-Chi Tsai Ya-Wen Tsai Yu-Chiang Wang Tzou-Yien Lin De-Jen Lee Chih-Jung Chen Humoral immunity to mumps in a highly vaccinated population in Taiwan Journal of Microbiology, Immunology and Infection |
author_facet |
Yu-Huai Ho Chen-Chi Tsai Ya-Wen Tsai Yu-Chiang Wang Tzou-Yien Lin De-Jen Lee Chih-Jung Chen |
author_sort |
Yu-Huai Ho |
title |
Humoral immunity to mumps in a highly vaccinated population in Taiwan |
title_short |
Humoral immunity to mumps in a highly vaccinated population in Taiwan |
title_full |
Humoral immunity to mumps in a highly vaccinated population in Taiwan |
title_fullStr |
Humoral immunity to mumps in a highly vaccinated population in Taiwan |
title_full_unstemmed |
Humoral immunity to mumps in a highly vaccinated population in Taiwan |
title_sort |
humoral immunity to mumps in a highly vaccinated population in taiwan |
publisher |
Elsevier |
series |
Journal of Microbiology, Immunology and Infection |
issn |
1684-1182 |
publishDate |
2019-06-01 |
description |
Background: A resurgence of mumps was noted recently and outbreaks were increasingly reported in populations with high vaccine coverage. We aimed to evaluate the seroprevalence to mumps in Taiwan, where a two-dose childhood mumps-containing vaccine program, with a high coverage rate, had been implemented for >20 years. Methods: The anti-mumps IgG was determined in 3552 participants of all ages in Taiwan. The age-specific seropositivity rates were calculated and the sociodemographic variables associated with the seronegative sera were analyzed with a logistic regression method. Results: The overall seroprevalence to mumps was 71%, with a higher rate in adults ≥19 years old than in the pediatric population <19 years old (80.4% versus 62.0%, P < 0.0001). In participants aged 2–20 years, who had been given at least one mumps-containing vaccine, the seropositivity fluctuated across different age subgroups and the lowest rate (36.8%) occurred in the 17–18 years age group. The multivariate analysis identified age within 17–18 years (adjusted odds ratio [aOR] 8.598, 95% confidence interval [CI] 2.990–24.722, P < 0.0001), within 19–20 years (aOR 5.076, 95% CI 1.702–15.133, P = 0.0080), and being a resident of the suburban area of northern Taiwan (aOR 1.089, 95% CI 0.823–1.414, P = 0.0008) as independent factors associated with an increased risk of seronegative sera. Conclusion: The seropositivity to mumps was unexpectedly low in highly vaccinated generations, and with a significant geographical discrepancy in Taiwan, which may have been responsible for the sustained reports of mumps cases in Taiwan. Keywords: Mumps, Seroprevalence, Humoral immunity, Taiwan |
url |
http://www.sciencedirect.com/science/article/pii/S168411821730227X |
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