Crosstalk between the Unfolded Protein Response and NF-κB-Mediated Inflammation in the Progression of Chronic Kidney Disease
The chronic inflammatory response is emerging as an important therapeutic target in progressive chronic kidney disease. A key transcription factor in the induction of chronic inflammation is NF-κB. Recent studies have demonstrated that sustained activation of the unfolded protein response (UPR) can...
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Online Access: | http://dx.doi.org/10.1155/2015/428508 |
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doaj-5c98c09d140047cc950fb21a6cb127ff2020-11-24T21:09:01ZengHindawi LimitedJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/428508428508Crosstalk between the Unfolded Protein Response and NF-κB-Mediated Inflammation in the Progression of Chronic Kidney DiseaseZahraa Mohammed-Ali0Gaile L. Cruz1Jeffrey G. Dickhout2Department of Medicine, Division of Nephrology, McMaster University and St. Joseph’s Healthcare Hamilton, 50 Charlton Avenue East, Hamilton, ON, L8N 4A6, CanadaDepartment of Medicine, Division of Nephrology, McMaster University and St. Joseph’s Healthcare Hamilton, 50 Charlton Avenue East, Hamilton, ON, L8N 4A6, CanadaDepartment of Medicine, Division of Nephrology, McMaster University and St. Joseph’s Healthcare Hamilton, 50 Charlton Avenue East, Hamilton, ON, L8N 4A6, CanadaThe chronic inflammatory response is emerging as an important therapeutic target in progressive chronic kidney disease. A key transcription factor in the induction of chronic inflammation is NF-κB. Recent studies have demonstrated that sustained activation of the unfolded protein response (UPR) can initiate this NF-κB signaling phenomenon and thereby induce chronic kidney disease progression. A key factor influencing chronic kidney disease progression is proteinuria and this condition has now been demonstrated to induce sustained UPR activation. This review details the crosstalk between the UPR and NF-κB pathways as pertinent to chronic kidney disease. We present potential tools to study this phenomenon as well as potential therapeutics that are emerging to regulate the UPR. These therapeutics may prevent inflammation specifically induced in the kidney due to proteinuria-induced sustained UPR activation.http://dx.doi.org/10.1155/2015/428508 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zahraa Mohammed-Ali Gaile L. Cruz Jeffrey G. Dickhout |
spellingShingle |
Zahraa Mohammed-Ali Gaile L. Cruz Jeffrey G. Dickhout Crosstalk between the Unfolded Protein Response and NF-κB-Mediated Inflammation in the Progression of Chronic Kidney Disease Journal of Immunology Research |
author_facet |
Zahraa Mohammed-Ali Gaile L. Cruz Jeffrey G. Dickhout |
author_sort |
Zahraa Mohammed-Ali |
title |
Crosstalk between the Unfolded Protein Response and NF-κB-Mediated Inflammation in the Progression of Chronic Kidney Disease |
title_short |
Crosstalk between the Unfolded Protein Response and NF-κB-Mediated Inflammation in the Progression of Chronic Kidney Disease |
title_full |
Crosstalk between the Unfolded Protein Response and NF-κB-Mediated Inflammation in the Progression of Chronic Kidney Disease |
title_fullStr |
Crosstalk between the Unfolded Protein Response and NF-κB-Mediated Inflammation in the Progression of Chronic Kidney Disease |
title_full_unstemmed |
Crosstalk between the Unfolded Protein Response and NF-κB-Mediated Inflammation in the Progression of Chronic Kidney Disease |
title_sort |
crosstalk between the unfolded protein response and nf-κb-mediated inflammation in the progression of chronic kidney disease |
publisher |
Hindawi Limited |
series |
Journal of Immunology Research |
issn |
2314-8861 2314-7156 |
publishDate |
2015-01-01 |
description |
The chronic inflammatory response is emerging as an important therapeutic target in progressive chronic kidney disease. A key transcription factor in the induction of chronic inflammation is NF-κB. Recent studies have demonstrated that sustained activation of the unfolded protein response (UPR) can initiate this NF-κB signaling phenomenon and thereby induce chronic kidney disease progression. A key factor influencing chronic kidney disease progression is proteinuria and this condition has now been demonstrated to induce sustained UPR activation. This review details the crosstalk between the UPR and NF-κB pathways as pertinent to chronic kidney disease. We present potential tools to study this phenomenon as well as potential therapeutics that are emerging to regulate the UPR. These therapeutics may prevent inflammation specifically induced in the kidney due to proteinuria-induced sustained UPR activation. |
url |
http://dx.doi.org/10.1155/2015/428508 |
work_keys_str_mv |
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