Modern concept of the etiology and pathogenesis of androgenetic alopecia
Introduction. The understanding of the etiology and pathogenesis of androgenetic alopecia (AGA) has formed modern therapeutic strategies for the treatment of this trichopathy. However, the significant prevalence of this pathology, limited therapeutic success, and differences in the response to stand...
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V. N. Karazin Kharkiv National University
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doaj-5c9c02be7fa84f79bae9a4830070c7cb2021-08-26T10:19:41ZengV. N. Karazin Kharkiv National UniversityJournal of V. N. Karazin Kharkiv National University: Series Medicine2313-66932313-23962021-07-0142429210010.26565/2313-6693-2021-42-11Modern concept of the etiology and pathogenesis of androgenetic alopeciaYuliya Ovcharenko0https://orcid.org/0000-0002-2412-2251Olena Salyenkova1https://orcid.org/0000-0001-5170-5447PhD, Professor, Department of infectious diseases and clinical immunology, V. N. Karazin Kharkiv National University, Medical Facultyасистент кафедри інфекційних хвороб та клінічної імунології, Харківський національний університет імені В. Н. Каразіна, медичний факультеIntroduction. The understanding of the etiology and pathogenesis of androgenetic alopecia (AGA) has formed modern therapeutic strategies for the treatment of this trichopathy. However, the significant prevalence of this pathology, limited therapeutic success, and differences in the response to standard therapy in male and female patients determine the interest in a more in-depth study and search for new links in the etiopathogenesis of AGA. Goal. Using a review of scientific publications in recent years on AGA in male and female patients, analyze and formulate the modern concept of the etiology and pathogenesis of this disease in order to further search for new treatment methods. Materials and methods. We searched and analyzed publications for the query «androgenetic alopecia, etiology, pathogenesis», the search was carried out using Google Scholar, considered articles that have been published since 2016. Results. The effect of androgens on hair follicles in androgen-dependent areas of the scalp under conditions of genetic predisposition is considered as the most studied and proven concept of AGA etiopathogenesis. However, recent studies have also revealed nonandrogenic cofactors, among which the pathological cascade of events «oxidative stress-microinflammation-fibrosis», which are determined at different stages of disease progression, is potentially interesting for further study. Knowledge of the phenomenon of apoptosis as an important factor in the disturbance of the dynamics of the hair cycle has been expanded. The management of perifollicular microinflammation and apoptosis can allow the control of the processes of sequential hair miniaturization and give a pronounced clinical result during the treatment of AGA. Thus, the nonandrogenic mechanisms of AGA pathobiology require further study. Conclusions. New data on the causes and mechanism of development of androgenetic alopecia in women and men have expanded our understanding of these processes. The need to supplement knowledge on this topic causes significant scientific interest and is very relevant, since they can be used to improve treatment for use in practical medicine.https://periodicals.karazin.ua/medicine/article/view/17491androgenetic alopeciaandrogensapoptosisetiologymicroinflammationoxidative stressfibrosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yuliya Ovcharenko Olena Salyenkova |
spellingShingle |
Yuliya Ovcharenko Olena Salyenkova Modern concept of the etiology and pathogenesis of androgenetic alopecia Journal of V. N. Karazin Kharkiv National University: Series Medicine androgenetic alopecia androgens apoptosis etiology microinflammation oxidative stress fibrosis |
author_facet |
Yuliya Ovcharenko Olena Salyenkova |
author_sort |
Yuliya Ovcharenko |
title |
Modern concept of the etiology and pathogenesis of androgenetic alopecia |
title_short |
Modern concept of the etiology and pathogenesis of androgenetic alopecia |
title_full |
Modern concept of the etiology and pathogenesis of androgenetic alopecia |
title_fullStr |
Modern concept of the etiology and pathogenesis of androgenetic alopecia |
title_full_unstemmed |
Modern concept of the etiology and pathogenesis of androgenetic alopecia |
title_sort |
modern concept of the etiology and pathogenesis of androgenetic alopecia |
publisher |
V. N. Karazin Kharkiv National University |
series |
Journal of V. N. Karazin Kharkiv National University: Series Medicine |
issn |
2313-6693 2313-2396 |
publishDate |
2021-07-01 |
description |
Introduction. The understanding of the etiology and pathogenesis of androgenetic alopecia (AGA) has formed modern therapeutic strategies for the treatment of this trichopathy. However, the significant prevalence of this pathology, limited therapeutic success, and differences in the response to standard therapy in male and female patients determine the interest in a more in-depth study and search for new links in the etiopathogenesis of AGA.
Goal. Using a review of scientific publications in recent years on AGA in male and female patients, analyze and formulate the modern concept of the etiology and pathogenesis of this disease in order to further search for new treatment methods.
Materials and methods. We searched and analyzed publications for the query «androgenetic alopecia, etiology, pathogenesis», the search was carried out using Google Scholar, considered articles that have been published since 2016.
Results. The effect of androgens on hair follicles in androgen-dependent areas of the scalp under conditions of genetic predisposition is considered as the most studied and proven concept of AGA etiopathogenesis. However, recent studies have also revealed nonandrogenic cofactors, among which the pathological cascade of events «oxidative stress-microinflammation-fibrosis», which are determined at different stages of disease progression, is potentially interesting for further study. Knowledge of the phenomenon of apoptosis as an important factor in the disturbance of the dynamics of the hair cycle has been expanded. The management of perifollicular microinflammation and apoptosis can allow the control of the processes of sequential hair miniaturization and give a pronounced clinical result during the treatment of AGA. Thus, the nonandrogenic mechanisms of AGA pathobiology require further study.
Conclusions. New data on the causes and mechanism of development of androgenetic alopecia in women and men have expanded our understanding of these processes. The need to supplement knowledge on this topic causes significant scientific interest and is very relevant, since they can be used to improve treatment for use in practical medicine. |
topic |
androgenetic alopecia androgens apoptosis etiology microinflammation oxidative stress fibrosis |
url |
https://periodicals.karazin.ua/medicine/article/view/17491 |
work_keys_str_mv |
AT yuliyaovcharenko modernconceptoftheetiologyandpathogenesisofandrogeneticalopecia AT olenasalyenkova modernconceptoftheetiologyandpathogenesisofandrogeneticalopecia |
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1721195680415875072 |