Cancer genes hypermethylated in human embryonic stem cells.
Developmental genes are silenced in embryonic stem cells by a bivalent histone-based chromatin mark. It has been proposed that this mark also confers a predisposition to aberrant DNA promoter hypermethylation of tumor suppressor genes (TSGs) in cancer. We report here that silencing of a significant...
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2008-09-01
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doaj-5c9e288ab70f4485a515a9c0508920fa2020-11-25T02:03:10ZengPublic Library of Science (PLoS)PLoS ONE1932-62032008-09-0139e329410.1371/journal.pone.0003294Cancer genes hypermethylated in human embryonic stem cells.Vincenzo CalvaneseAngelica HorrilloAbdelkrim HmadchaBeatriz Suarez-AlvarezAgustín F FernandezEster LaraSara CasadoPablo MenendezClara BuenoJavier Garcia-CastroRuth RubioPablo LapunzinaMiguel AlaminosLodovica BorgheseStefanie TersteggeNeil J HarrisonHarry D MooreOliver BrüstleCarlos Lopez-LarreaPeter W AndrewsBernat SoriaManel EstellerMario F FragaDevelopmental genes are silenced in embryonic stem cells by a bivalent histone-based chromatin mark. It has been proposed that this mark also confers a predisposition to aberrant DNA promoter hypermethylation of tumor suppressor genes (TSGs) in cancer. We report here that silencing of a significant proportion of these TSGs in human embryonic and adult stem cells is associated with promoter DNA hypermethylation. Our results indicate a role for DNA methylation in the control of gene expression in human stem cells and suggest that, for genes repressed by promoter hypermethylation in stem cells in vivo, the aberrant process in cancer could be understood as a defect in establishing an unmethylated promoter during differentiation, rather than as an anomalous process of de novo hypermethylation.http://europepmc.org/articles/PMC2546447?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vincenzo Calvanese Angelica Horrillo Abdelkrim Hmadcha Beatriz Suarez-Alvarez Agustín F Fernandez Ester Lara Sara Casado Pablo Menendez Clara Bueno Javier Garcia-Castro Ruth Rubio Pablo Lapunzina Miguel Alaminos Lodovica Borghese Stefanie Terstegge Neil J Harrison Harry D Moore Oliver Brüstle Carlos Lopez-Larrea Peter W Andrews Bernat Soria Manel Esteller Mario F Fraga |
spellingShingle |
Vincenzo Calvanese Angelica Horrillo Abdelkrim Hmadcha Beatriz Suarez-Alvarez Agustín F Fernandez Ester Lara Sara Casado Pablo Menendez Clara Bueno Javier Garcia-Castro Ruth Rubio Pablo Lapunzina Miguel Alaminos Lodovica Borghese Stefanie Terstegge Neil J Harrison Harry D Moore Oliver Brüstle Carlos Lopez-Larrea Peter W Andrews Bernat Soria Manel Esteller Mario F Fraga Cancer genes hypermethylated in human embryonic stem cells. PLoS ONE |
author_facet |
Vincenzo Calvanese Angelica Horrillo Abdelkrim Hmadcha Beatriz Suarez-Alvarez Agustín F Fernandez Ester Lara Sara Casado Pablo Menendez Clara Bueno Javier Garcia-Castro Ruth Rubio Pablo Lapunzina Miguel Alaminos Lodovica Borghese Stefanie Terstegge Neil J Harrison Harry D Moore Oliver Brüstle Carlos Lopez-Larrea Peter W Andrews Bernat Soria Manel Esteller Mario F Fraga |
author_sort |
Vincenzo Calvanese |
title |
Cancer genes hypermethylated in human embryonic stem cells. |
title_short |
Cancer genes hypermethylated in human embryonic stem cells. |
title_full |
Cancer genes hypermethylated in human embryonic stem cells. |
title_fullStr |
Cancer genes hypermethylated in human embryonic stem cells. |
title_full_unstemmed |
Cancer genes hypermethylated in human embryonic stem cells. |
title_sort |
cancer genes hypermethylated in human embryonic stem cells. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2008-09-01 |
description |
Developmental genes are silenced in embryonic stem cells by a bivalent histone-based chromatin mark. It has been proposed that this mark also confers a predisposition to aberrant DNA promoter hypermethylation of tumor suppressor genes (TSGs) in cancer. We report here that silencing of a significant proportion of these TSGs in human embryonic and adult stem cells is associated with promoter DNA hypermethylation. Our results indicate a role for DNA methylation in the control of gene expression in human stem cells and suggest that, for genes repressed by promoter hypermethylation in stem cells in vivo, the aberrant process in cancer could be understood as a defect in establishing an unmethylated promoter during differentiation, rather than as an anomalous process of de novo hypermethylation. |
url |
http://europepmc.org/articles/PMC2546447?pdf=render |
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