COMPARATIVE STUDIES ON SYNTHESIS AND STRUCTURE OF OLD AND NEW POLYMORPHS OF DESVENLAFAXINE - AN ANTIDEPRESSANT DRUG

COMPARATIVE STUDIES ON SYNTHESIS AND STRUCTURE OF OLD AND NEW POLYMORPHS OF DESVENLAFAXINE - AN ANTIDEPRESSANT DRUG

Desvenlafaxine succinate (pristiq) is an important nonhormonal drug used in the treatment of major depressive disorder and problems associated with menopause.This article summarizes the synthesis and investigation of new polymorphic form of Desmethylvenlafaxine. The new polymorph has been compa...

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Main Authors: Mahendra Khandpekar, Jayanta Mheta, Sanjay Patil, Sonali Araj, Pandurang Satpute
Format: Article
Language:English
Published: Universitas Gadjah Mada 2014-01-01
Series:Indonesian Journal of Pharmacy
Subjects:
desvenlafaxine
polymorphism
structure
crystalline
purity
Online Access:http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/15
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spelling doaj-5cb2a9a7e1254e3ba6a98c8655dd74642020-11-25T00:17:36ZengUniversitas Gadjah MadaIndonesian Journal of Pharmacy2338-94272338-94862014-01-01251253010.14499/indonesianjpharm25iss1pp25COMPARATIVE STUDIES ON SYNTHESIS AND STRUCTURE OF OLD AND NEW POLYMORPHS OF DESVENLAFAXINE - AN ANTIDEPRESSANT DRUG Mahendra Khandpekar0Jayanta Mheta1Sanjay Patil2Sonali Araj3Pandurang Satpute4Materials Research Lab, Department of Physics, Birla College, Kalyan – 421 304, IndiaDepartment of Chemistry, Changu Kana Thakur, Arts, Commerce and Science College, New Panvel, Raigad - 410 206, India Department of Chemistry, Changu Kana Thakur, Arts, Commerce and Science College, New Panvel, Raigad - 410 206, India Department of Chemistry, Changu Kana Thakur, Arts, Commerce and Science College, New Panvel, Raigad - 410 206, India Department of Chemistry, Birla College, Kalyan – 421 304, India.Desvenlafaxine succinate (pristiq) is an important nonhormonal drug used in the treatment of major depressive disorder and problems associated with menopause.This article summarizes the synthesis and investigation of new polymorphic form of Desmethylvenlafaxine. The new polymorph has been compared with the old polymorph using XRD, DSC, FTIR, SEM and HPLC techniques. Three prominent reflections with higher intensities lying at 20.3, 13.1 and 15.8 have been noted in the XRD measurements for the new polymorph. Higher intensity (XRD) peaks for the new polymorph indicates good crystalline quality. FTIR spectra shows close match between the polymorphs. DSC measurements show enhanced thermal stability for the new polymorph. Higher purity is indicated by the HPLC studies. http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/15desvenlafaxinepolymorphismstructurecrystallinepurity
collection DOAJ
language English
format Article
sources DOAJ
author Mahendra Khandpekar
Jayanta Mheta
Sanjay Patil
Sonali Araj
Pandurang Satpute
spellingShingle Mahendra Khandpekar
Jayanta Mheta
Sanjay Patil
Sonali Araj
Pandurang Satpute
COMPARATIVE STUDIES ON SYNTHESIS AND STRUCTURE OF OLD AND NEW POLYMORPHS OF DESVENLAFAXINE - AN ANTIDEPRESSANT DRUG
Indonesian Journal of Pharmacy
desvenlafaxine
polymorphism
structure
crystalline
purity
author_facet Mahendra Khandpekar
Jayanta Mheta
Sanjay Patil
Sonali Araj
Pandurang Satpute
author_sort Mahendra Khandpekar
title COMPARATIVE STUDIES ON SYNTHESIS AND STRUCTURE OF OLD AND NEW POLYMORPHS OF DESVENLAFAXINE - AN ANTIDEPRESSANT DRUG
title_short COMPARATIVE STUDIES ON SYNTHESIS AND STRUCTURE OF OLD AND NEW POLYMORPHS OF DESVENLAFAXINE - AN ANTIDEPRESSANT DRUG
title_full COMPARATIVE STUDIES ON SYNTHESIS AND STRUCTURE OF OLD AND NEW POLYMORPHS OF DESVENLAFAXINE - AN ANTIDEPRESSANT DRUG
title_fullStr COMPARATIVE STUDIES ON SYNTHESIS AND STRUCTURE OF OLD AND NEW POLYMORPHS OF DESVENLAFAXINE - AN ANTIDEPRESSANT DRUG
title_full_unstemmed COMPARATIVE STUDIES ON SYNTHESIS AND STRUCTURE OF OLD AND NEW POLYMORPHS OF DESVENLAFAXINE - AN ANTIDEPRESSANT DRUG
title_sort comparative studies on synthesis and structure of old and new polymorphs of desvenlafaxine - an antidepressant drug
publisher Universitas Gadjah Mada
series Indonesian Journal of Pharmacy
issn 2338-9427
2338-9486
publishDate 2014-01-01
description Desvenlafaxine succinate (pristiq) is an important nonhormonal drug used in the treatment of major depressive disorder and problems associated with menopause.This article summarizes the synthesis and investigation of new polymorphic form of Desmethylvenlafaxine. The new polymorph has been compared with the old polymorph using XRD, DSC, FTIR, SEM and HPLC techniques. Three prominent reflections with higher intensities lying at 20.3, 13.1 and 15.8 have been noted in the XRD measurements for the new polymorph. Higher intensity (XRD) peaks for the new polymorph indicates good crystalline quality. FTIR spectra shows close match between the polymorphs. DSC measurements show enhanced thermal stability for the new polymorph. Higher purity is indicated by the HPLC studies.
topic desvenlafaxine
polymorphism
structure
crystalline
purity
url http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/15
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AT sanjaypatil comparativestudiesonsynthesisandstructureofoldandnewpolymorphsofdesvenlafaxineanantidepressantdrug
AT sonaliaraj comparativestudiesonsynthesisandstructureofoldandnewpolymorphsofdesvenlafaxineanantidepressantdrug
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