Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease

B cells are important for antigen presentation and antibody production in humoral immunity, but are also increasingly recognized for their immune regulatory functions. Here the authors show that HIF-1α, a hypoxia-induced transcription factor, is important for controlling IL-10 induction in and immun...

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Main Authors:	Xianyi Meng, Bettina Grötsch, Yubin Luo, Karl Xaver Knaup, Michael Sean Wiesener, Xiao-Xiang Chen, Jonathan Jantsch, Simon Fillatreau, Georg Schett, Aline Bozec
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-02683-x

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spelling	doaj-5ccd5d39b25f4edd9af12b6f1ad0ddfa2021-05-11T09:51:17ZengNature Publishing GroupNature Communications2041-17232018-01-019111710.1038/s41467-017-02683-xHypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune diseaseXianyi Meng0Bettina Grötsch1Yubin Luo2Karl Xaver Knaup3Michael Sean Wiesener4Xiao-Xiang Chen5Jonathan Jantsch6Simon Fillatreau7Georg Schett8Aline Bozec9Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum ErlangenDepartment of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum ErlangenDepartment of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum ErlangenDepartment of Internal Medicine 4, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum ErlangenDepartment of Internal Medicine 4, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum ErlangenDepartment of Rheumatology, Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineInstitute of Clinical Microbiology and Hygiena, University Hospital of Regensburg, University of RegensburgInstitut Necker-Enfants Malades (INEM), INSERM U1151-CNRS UMR 8253, Université Paris DescartesDepartment of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum ErlangenDepartment of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum ErlangenB cells are important for antigen presentation and antibody production in humoral immunity, but are also increasingly recognized for their immune regulatory functions. Here the authors show that HIF-1α, a hypoxia-induced transcription factor, is important for controlling IL-10 induction in and immune-suppressive activity of B cells.https://doi.org/10.1038/s41467-017-02683-x
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Xianyi Meng Bettina Grötsch Yubin Luo Karl Xaver Knaup Michael Sean Wiesener Xiao-Xiang Chen Jonathan Jantsch Simon Fillatreau Georg Schett Aline Bozec
spellingShingle	Xianyi Meng Bettina Grötsch Yubin Luo Karl Xaver Knaup Michael Sean Wiesener Xiao-Xiang Chen Jonathan Jantsch Simon Fillatreau Georg Schett Aline Bozec Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease Nature Communications
author_facet	Xianyi Meng Bettina Grötsch Yubin Luo Karl Xaver Knaup Michael Sean Wiesener Xiao-Xiang Chen Jonathan Jantsch Simon Fillatreau Georg Schett Aline Bozec
author_sort	Xianyi Meng
title	Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease
title_short	Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease
title_full	Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease
title_fullStr	Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease
title_full_unstemmed	Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease
title_sort	hypoxia-inducible factor-1α is a critical transcription factor for il-10-producing b cells in autoimmune disease
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-01-01
description	B cells are important for antigen presentation and antibody production in humoral immunity, but are also increasingly recognized for their immune regulatory functions. Here the authors show that HIF-1α, a hypoxia-induced transcription factor, is important for controlling IL-10 induction in and immune-suppressive activity of B cells.
url	https://doi.org/10.1038/s41467-017-02683-x
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Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease

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