Genetic Modification of Tumor-Infiltrating Lymphocytes via Retroviral Transduction

Genetic Modification of Tumor-Infiltrating Lymphocytes via Retroviral Transduction

Adoptive T cell therapy (ACT) holds great promise for cancer treatment. One approach, which has regained wide interest in recent years, employs antitumor T cells isolated from tumor lesions (“tumor-infiltrating lymphocytes” or TIL). It is now appreciated that a considerable proportion of anti-melano...

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Bibliographic Details
Main Authors: Hadas Weinstein-Marom, Gideon Gross, Michal Levi, Hadar Brayer, Jacob Schachter, Orit Itzhaki, Michal J. Besser
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
adoptive cell therapy
rapid expansion protocol
T cell subsets
T cell differentiation status
chimeric antigen receptors
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.584148/full

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