Linezolid Dependence in Staphylococcus epidermidis Bloodstream Isolates

Linezolid Dependence in Staphylococcus epidermidis Bloodstream Isolates

We document linezolid dependence among 5 highly linezolid-resistant (LRSE) Staphylococcus epidermidis bloodstream isolates that grew substantially faster at 32 µg/mL linezolid presence. These isolates carried the mutations T2504A and C2534T in multiple 23S rRNA copies and 2 mutations leading to rele...

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Main Authors: Spyros Pournaras, Eleni Ntokou, Olympia Zarkotou, Kyriaki Ranellou, Katerina Themeli-Digalaki, Constantinos Stathopoulos, Athanassios Tsakris
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2013-01-01
Series:Emerging Infectious Diseases
Subjects:
L3 mutations
23S rDNA mutations
growth rate
protein synthesis
ribosome
Staphylococcus epidermidis
Online Access:https://wwwnc.cdc.gov/eid/article/19/1/11-1527_article
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spelling doaj-5cdf9303fcdd45b282cd8504e0eb55312020-11-24T21:52:56ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592013-01-0119112913210.3201/eid1901.111527Linezolid Dependence in Staphylococcus epidermidis Bloodstream IsolatesSpyros PournarasEleni NtokouOlympia ZarkotouKyriaki RanellouKaterina Themeli-DigalakiConstantinos StathopoulosAthanassios TsakrisWe document linezolid dependence among 5 highly linezolid-resistant (LRSE) Staphylococcus epidermidis bloodstream isolates that grew substantially faster at 32 µg/mL linezolid presence. These isolates carried the mutations T2504A and C2534T in multiple 23S rRNA copies and 2 mutations leading to relevant amino acid substitutions in L3 protein. Linezolid dependence could account for increasing LRSE emergence.https://wwwnc.cdc.gov/eid/article/19/1/11-1527_articleL3 mutations23S rDNA mutationsgrowth rateprotein synthesisribosomeStaphylococcus epidermidis
collection DOAJ
language English
format Article
sources DOAJ
author Spyros Pournaras
Eleni Ntokou
Olympia Zarkotou
Kyriaki Ranellou
Katerina Themeli-Digalaki
Constantinos Stathopoulos
Athanassios Tsakris
spellingShingle Spyros Pournaras
Eleni Ntokou
Olympia Zarkotou
Kyriaki Ranellou
Katerina Themeli-Digalaki
Constantinos Stathopoulos
Athanassios Tsakris
Linezolid Dependence in Staphylococcus epidermidis Bloodstream Isolates
Emerging Infectious Diseases
L3 mutations
23S rDNA mutations
growth rate
protein synthesis
ribosome
Staphylococcus epidermidis
author_facet Spyros Pournaras
Eleni Ntokou
Olympia Zarkotou
Kyriaki Ranellou
Katerina Themeli-Digalaki
Constantinos Stathopoulos
Athanassios Tsakris
author_sort Spyros Pournaras
title Linezolid Dependence in Staphylococcus epidermidis Bloodstream Isolates
title_short Linezolid Dependence in Staphylococcus epidermidis Bloodstream Isolates
title_full Linezolid Dependence in Staphylococcus epidermidis Bloodstream Isolates
title_fullStr Linezolid Dependence in Staphylococcus epidermidis Bloodstream Isolates
title_full_unstemmed Linezolid Dependence in Staphylococcus epidermidis Bloodstream Isolates
title_sort linezolid dependence in staphylococcus epidermidis bloodstream isolates
publisher Centers for Disease Control and Prevention
series Emerging Infectious Diseases
issn 1080-6040
1080-6059
publishDate 2013-01-01
description We document linezolid dependence among 5 highly linezolid-resistant (LRSE) Staphylococcus epidermidis bloodstream isolates that grew substantially faster at 32 µg/mL linezolid presence. These isolates carried the mutations T2504A and C2534T in multiple 23S rRNA copies and 2 mutations leading to relevant amino acid substitutions in L3 protein. Linezolid dependence could account for increasing LRSE emergence.
topic L3 mutations
23S rDNA mutations
growth rate
protein synthesis
ribosome
Staphylococcus epidermidis
url https://wwwnc.cdc.gov/eid/article/19/1/11-1527_article
work_keys_str_mv AT spyrospournaras linezoliddependenceinstaphylococcusepidermidisbloodstreamisolates
AT elenintokou linezoliddependenceinstaphylococcusepidermidisbloodstreamisolates
AT olympiazarkotou linezoliddependenceinstaphylococcusepidermidisbloodstreamisolates
AT kyriakiranellou linezoliddependenceinstaphylococcusepidermidisbloodstreamisolates
AT katerinathemelidigalaki linezoliddependenceinstaphylococcusepidermidisbloodstreamisolates
AT constantinosstathopoulos linezoliddependenceinstaphylococcusepidermidisbloodstreamisolates
AT athanassiostsakris linezoliddependenceinstaphylococcusepidermidisbloodstreamisolates
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