The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases
Neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS), currently affect more than 6 million people in the United States. Unfortunately, there are no treatments that sl...
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doaj-5cedabc87764420693add436fa8188a02020-11-24T21:54:17ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-06-012012305610.3390/ijms20123056ijms20123056The Potential of Flavonoids for the Treatment of Neurodegenerative DiseasesPamela Maher0Salk Institute for Biological Studies, La Jolla, CA 92037, USANeurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS), currently affect more than 6 million people in the United States. Unfortunately, there are no treatments that slow or prevent disease development and progression. Regardless of the underlying cause of the disorder, age is the strongest risk factor for developing these maladies, suggesting that changes that occur in the aging brain put it at increased risk for neurodegenerative disease development. Moreover, since there are a number of different changes that occur in the aging brain, it is unlikely that targeting a single change is going to be effective for disease treatment. Thus, compounds that have multiple biological activities that can impact the various age-associated changes in the brain that contribute to neurodegenerative disease development and progression are needed. The plant-derived flavonoids have a wide range of activities that could make them particularly effective for blocking the age-associated toxicity pathways associated with neurodegenerative diseases. In this review, the evidence for beneficial effects of multiple flavonoids in models of AD, PD, HD, and ALS is presented and common mechanisms of action are identified. Overall, the preclinical data strongly support further investigation of specific flavonoids for the treatment of neurodegenerative diseases.https://www.mdpi.com/1422-0067/20/12/3056oxidative stresscognitive dysfunctioninflammationcell deathsynapse lossprotein aggregationneurodegenerative disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pamela Maher |
spellingShingle |
Pamela Maher The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases International Journal of Molecular Sciences oxidative stress cognitive dysfunction inflammation cell death synapse loss protein aggregation neurodegenerative disease |
author_facet |
Pamela Maher |
author_sort |
Pamela Maher |
title |
The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases |
title_short |
The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases |
title_full |
The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases |
title_fullStr |
The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases |
title_full_unstemmed |
The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases |
title_sort |
potential of flavonoids for the treatment of neurodegenerative diseases |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-06-01 |
description |
Neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS), currently affect more than 6 million people in the United States. Unfortunately, there are no treatments that slow or prevent disease development and progression. Regardless of the underlying cause of the disorder, age is the strongest risk factor for developing these maladies, suggesting that changes that occur in the aging brain put it at increased risk for neurodegenerative disease development. Moreover, since there are a number of different changes that occur in the aging brain, it is unlikely that targeting a single change is going to be effective for disease treatment. Thus, compounds that have multiple biological activities that can impact the various age-associated changes in the brain that contribute to neurodegenerative disease development and progression are needed. The plant-derived flavonoids have a wide range of activities that could make them particularly effective for blocking the age-associated toxicity pathways associated with neurodegenerative diseases. In this review, the evidence for beneficial effects of multiple flavonoids in models of AD, PD, HD, and ALS is presented and common mechanisms of action are identified. Overall, the preclinical data strongly support further investigation of specific flavonoids for the treatment of neurodegenerative diseases. |
topic |
oxidative stress cognitive dysfunction inflammation cell death synapse loss protein aggregation neurodegenerative disease |
url |
https://www.mdpi.com/1422-0067/20/12/3056 |
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